Trimethoprim Cas: 738-70-5
| Catalog Number | XD92385 |
| Product Name | Trimethoprim |
| CAS | 738-70-5 |
| Molecular Formula | C14H18N4O3 |
| Molecular Weight | 290.32 |
| Storage Details | 2-8°C |
| Harmonised Tariff Code | 29335995 |
Chigadzirwa Specification
| Chitarisiko | Hupfu chena kana yero-chena |
| Assay | 99% min |
| Melting Point | 199 - 203 Deg C |
| Heavy metals | ≤20ppm |
| Kurasika paKuomesa | ≤1.0% |
| Related Substances | ≤0.2% |
| Solubility | Yakanyanya kunyungudika zvishoma mumvura, inonyungudika zvishoma mudoro, isinganyungudika muether |
Trimethoprim inonzi lipophilic uye isina simba alkaline pyrimethamine kirasi bacteriostatic agent.Ihwo hupfu huchena kana hunenge huchena hwekristaro, husina kunhuhwirira, hunovava, uye hunonyungudika zvishoma muchloroform, ethanol kana uye acetone, asi inenge isinganyungudike mumvura uye inonyungudika zvakanyanya mu glacial acetic acid solution.Iine antibacterial spectrum iyo yakafanana nemishonga ye sulfa, asi ine simba rinorwisa mabhakitiriya.Iine simba rakanaka pakurapa Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Staphylococcus saprophyticus, uye mamwe akasiyana-siyana e gram-positive uye mabhakitiriya asina kunaka.Asi haishande kurwisa hutachiona hwePseudomonas aeruginosa.Iyo shoma inhibitory concentration inowanzova isingasviki 10 mg/L nekushandisa chete kuri nyore kukonzera bhakitiriya kuramba, uye nekudaro haiwanzo shandiswa yoga, uye inonyanya kusanganiswa nesarufa mushonga kugadzira gadziriro yekomboni yekurapa kwekiriniki yehutachiona hwehutachiwana, intestinal. kutapukirwa, zvirwere zvekufema, dysentery, enteritis, fivha yetyphoid, meningitis, otitis media, meningitis, sepsis uye zvirwere zvinyoro zvinyoro.Iine simba pakurapa typhoid uye paratyphoid iyo isiri pasi peampicillin;Inogona zvakare kusanganiswa nemishonga ine sulfa yakareba-inoshanda yekudzivirira uye kurapwa kwefalciparum isingaite mishonga.
Nheyo yekutanga yeanti-bacterial ye trimethoprim ndeyekukanganisa folate metabolism mubhakitiriya.Iyo huru nzira yekuita ndeye yakasarudzika inhibition yebasa re dihydrofolate reductase mubhakitiriya kuitira kuti dihydrofolate irege kuderedzwa kusvika tetrahydrofolate.Sezvo iyo synthesis ye folic acid ndiyo chikamu chikuru cheiyo nucleic acid biosynthesis, uye saka chigadzirwa chinodzivirira bhakitiriya nucleic acids uye mapuroteni synthesis.Uyezve, iyo inosunga hukama hwe trimethoprim (TMP) kune bhakitiriya dihydrofolate reductase enzyme yakasimba zvakapetwa kashanu pane iyo kune mammalian dihydrofolate reductase.Iko kusanganiswa pakati payo nemishonga yesarufa kunogona kukonzera kuvharika kuviri kune folic acid biosynthesis metabolism yebhakitiriya kuitira kuti pave ne synergistic mhedzisiro inosimudzira basa reantibacterial yemishonga yesulfa, uye inogona kushandura antibacterial mhedzisiro kuita bactericidal mhedzisiro inoderedza kusagadzikana kwemishonga. strains.Mukuwedzera, chigadzirwa chacho chinogonawo kuwedzera antibacterial migumisiro yezvimwe zvakasiyana-siyana zvemishonga inorwisa mabhakitiriya (senge tetracycline, gentamicin).
