Uridine-5'-diphosphoglucuronic acid trisodium munyu CAS: 63700-19-6 Hupfu chena
| Catalog Number | XD90382 |
| Product Name | Uridine-5'-diphosphoglucuronic acid trisodium munyu |
| CAS | 63700-19-6 |
| Molecular Formula | C15H19N2O18P2Na3 |
| Molecular Weight | 646.20 |
| Storage Details | < -4 °C |
Chigadzirwa Specification
| Assay | 99% |
| Chitarisiko | Upfu chena |
Chidzidzo chazvino chine chinangwa chekuongorora pesvedzero yehupfu hweirinotecan neiyo biotransformation yeglucoaurantio-obtusin kune aurantio-obtusin.Intraperitoneal administration (ip) ye100 mg/kg aurantio-obtusin yakawedzera zvakanyanya huturu hweirinotecan, asi ip administration ye100 mg/kg glucoaurantio-obtusin yakaratidza simba risingakoshi kune irinotecan's toxicity.Uyezve, iyo michina yakatsanangurwa kuburikidza nekuona inhibition kugona kweglucoaurantio-obtusin uye aurantio-obtusin yakanangana neglucuronidation metabolism yeSN-38 iyo yave ichionekwa sechigadzirwa chikuru chinoshanda chinokonzera huturu hweirinotecan.Mhedzisiro yacho yakaratidza kuti aurantio-obtusin yakaratidza kukwikwidza kwakasimba kudzvinyirirwa kune glucuronidation yeSN-38, asi isingagoneki inhibition inogona yeglucoaurantio-obtusin yakananga kuSN-38 glucuronidation yakaonekwa.Mhedzisiro iyi yakaratidza kuti biotransformation yeglucoaurantio-obtusin yakananga kuaurantio-obtusin yakawedzera huturu hweirinotecan kuburikidza nekuwedzera inhibition yeSN-38 glucuronidation.
