2′-Deoxyuridine Cas:951-78-0
| Catalog Number | XD90583 |
| Product Name | 2'-Deoxyuridine |
| CAS | 951-78-0 |
| Molecular Formula | C9H12N2O5 |
| Molecular Weight | 228.20 |
| Storage Details | 2 kusvika ku8 °C |
| Harmonised Tariff Code | 29349990 |
Chigadzirwa Specification
| Chitarisiko | Hupfu hwakachena kusvika kuchena |
| Assay | 99% |
| Melting Point | 164 - 168 Deg C |
| Kurasika paKuomesa | <1.0% |
| Residue paIgnition | <0.1% |
Kuvandudzwa kwekushandiswa kwenitrogen mumombe kwakakosha kuitira kuchengetedza mombe dzinogara dziripo.Sezvo purine uye pyrimidines (PP) ichiumba chikamu chinoyemurika cherumen nitrogen, kunzwisiswa kwakavandudzika kwekunyudzwa uye yepakati metabolism yePP kwakakosha.Basa remazuva ano rinotsanangura kukurudzirwa uye kusimbiswa kweimwe nzira inonzwisisika uye yakananga yekugadza panguva imwe chete ye20 purines (adenine, guanine, guanosine, inosine, 2'-deoxyguanosine, 2'-deoxyinosine, xanthine, hypoxanthine), pyrimidines (cytosine, thymine, uracil, cytidine, uridine, thymidine, 2'-deoxyuridine), uye zvigadzirwa zvavo zvekuora (uric acid, allantoin, β-alanine, β-ureidopropionic acid, β-aminoisobutyric acid) muropa plasma yemombe dzemukaka.Iyo yakakwira performance liquid chromatography-based technique yakasanganiswa neelectrospray ionization tandem mass spectrometry (LC-MS/MS) yakasanganiswa neyega matrix-inofananidzwa necalibration zviyero uye yakagadzikana isotopically yakanyorwa mareferenzi makomisheni.Ongororo yehuwandu yakatangirwa neinowani pre-kurapa maitiro anosanganisira ethanol kunaya, kusefa, evaporation uye kugadzirisa zvakare.Parameters yekuparadzanisa uye kuonekwa panguva yeLC-MS / MS kuongororwa kwakaongororwa.Izvo zvakasimbiswa kuti kushandisa iyo log-calibration modhi pane mutsara calibration modhi yakakonzera yakaderera CV% uye kushomeka kwemuyedzo wakakodzera kwakaratidza kugutsikana kwemutsara kudzoreredza.Iyo nzira inovhara mazinga eiyo metabolite yega yega zvichienderana neiyo mumasampuli chaiwo, semuenzaniso guanine: 0.10-5.0 μmol/L, uye allantoin: 120-500 μmol/L.Iyo CV% yeakasarudzwa quantification renji yaive pazasi 25%.Iyo nzira ine yakanaka kudzokorora (CV% ≤25%) uye yepakati chaiyo (CV% ≤25%) uye yakanakisa kupora (91-107%).Metabolites yese yakaratidza kugadzikana kwakanaka kwenguva refu uye kugadzikana kwakanaka mukati-inomhanya (CV% ≤10%).Madhigirii akasiyana eabsolute matrix mhedzisiro akaonekwa muplasma, weti nemukaka.Kutemerwa kwehukama hwematrix mhedzisiro kwakaratidza kuti nzira yacho yaive yakakodzera kune angangoita ese akaongororwa PP metabolites muplasma inotorwa kubva kune artery uye portal hepatic, hepatic uye gastrosplenic tsinga uye, kunze kwezvishoma, zvakare kune mamwe marudzi sehuku, nguruve, mink, munhu uye gonzo.
