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(3R,4R) -1-(tert-Butoxycarbonyl) -4-methylpyrrolidine-3-carboxylic acid, inozivikanwawo seBoc-4-methylproline, ikemikari inobatanidza zvakanyanya kushandiswa mumunda we organic synthesis, kunyanya mukugadzirwa kwe peptides uye peptidomimetics yezvikumbiro zvakasiyana-siyana.Chimwe chekushandiswa kukuru kweBoc-4-methylproline iboka rinodzivirira reboka remamino acids panguva yepeptide synthesis.Mapoka ekudzivirira magadzirirwo enguva pfupi anodzivirira chaiwo mapoka anoshanda emamorekuru kudzivirira maitiro asingadiwe panguva yekugadzira.Mu peptide synthesis, Boc-4-methylproline inoshandiswa seboka rinodzivirira reboka reamine, zvichiita kuti kusarudzwa kusungirirwa kwemamwe amino acids kuumba inodiwa peptide sequence.Boc-4-methylproline inoshandawo sechiral building block mu kuumbwa kweakasiyana makomboni ane zvingangoita biological zviitiko.Sechiral compound, ine stereocenter, zvichiita kuti inantiomers mbiri: (3R,4R) -Boc-4-methylproline uye (3S,4S) -Boc-4-methylproline.Imwe neimwe enantiomer inogona kuratidza akasiyana pharmacological zvivakwa uye kudyidzana nebiological zvinangwa.Nokushandisa Boc-4-methylproline sechinhu chekutanga, makemikari anogona kuwana huwandu hwechiral compounds yekutsvaga zvinodhaka uye kubudirira.Uyezve, Boc-4-methylproline derivatives yakaratidza maitiro emishonga, antiviral, uye anticancer.Makomponi aya akaferefetwa kuitira kugona kwawo seanorapa kurwisa zvirwere zvakasiyana siyana, kusanganisira mabhakitiriya, mavhairasi, uye maseru egomarara.Nekugadzirisa maumbirwo eBoc-4-methylproline uye kuongorora mabudiro ayo, vatsvakurudzi vanogona kuongorora zvavanogona semishonga inotungamira kana scaffold molecules yekugadzirwa kwezvinodhaka.Kuwedzera kune mashandisirwo ayo mu peptide synthesis uye kukura kwezvinodhaka, Boc-4-methylproline inoshandiswawo. mukugadzira peptidomimetics.Peptidomimetics makomisheni anotevedzera chimiro uye basa remapeptides asi ane kusimba kwakawedzera uye pharmacokinetic zvimiro.Boc-4-methylproline inogona kushanda sechivakwa mukugadzira uye kuumbwa kwepeptidomimetics, ichibvumira kuvandudzwa kwenovel therapeutics nekuvandudzwa kwebioavailability uye chinangwa chaicho.Muchidimbu, (3R,4R) -1-(tert-Butoxycarbonyl) - 4-methylpyrrolidine-3-carboxylic acid, kana Boc-4-methylproline, inhengo inosiyana-siyana inoshandiswa zvakanyanya mukugadzirwa kwehupenyu.Basa rayo seboka rinodzivirira mune peptide synthesis, pamwe neiyo chiral zvimiro, inoita kuti ive chivakwa chakakosha chekugadzira peptides, peptidomimetics, uye chiral makomisheni.Izvo zvinobva kuBoc-4-methylproline zvinoferefetwa kune zvavanogona kuita zvipenyu, izvo zvinosanganisira antimicrobial, antiviral, uye anticancer properties.Kuenderera mberi nekutsvagisa uye hunyanzvi mukushandisa Boc-4-methylproline mukugadzira zvinodhaka kunobatsira mukugadzirwa kwemishonga mitsva yekurapa uye kunatsiridza manzwisisiro edu ezvakaoma zvipenyu maitiro.