Products

(+)-(3R,5S), tert-Butyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonylamino)-pyrimidin-5-yl]-3,5 -dihydroxy-6 (E) -heptenate, inozivikanwawo seR1.5 kana tert-butyl-rosuvastatin, ikemikari inosanganiswa inogona kushandiswa muindasitiri yemishonga.Rosuvastatin inonyanya kuzivikanwa cholesterol-inoderedza mishonga yekirasi. zvinodhaka zvinonzi statins.Inoshanda nekudzivisa enzyme inonzi HMG-CoA reductase, iyo inobatanidzwa mukugadzirwa kwecholesterol mumuviri.R1.5 inogadzirwa ne rosuvastatin ine boka re tert-butyl rakasungirirwa kune molecule, richipa mamwe maitiro uye zvingave zvikomborero.Imwe inogona kushandiswa yeR1.5 semishonga yemishonga yekurapa hyperlipidemia nekudzivirira zvirwere zvemwoyo.Kufanana nerosuvastatin, R1.5 inogona kushandiswa kuderedza mazinga eLDL cholesterol, inozivikanwawo se "yakaipa" cholesterol, uye triglycerides muropa.Mushonga uyu unogona kuratidza yakagadziridzwa pharmacokinetic zvimiro, senge kuwedzera bioavailability kana kusimbaradzika, zvichienzaniswa nemushonga wemubereki.Uyezve, boka re-tert-butyl rinogona kuita kuti musanganisi wekomboni inyunguduke uye igadzirwe zvakasiyana-siyana, zvichiita kuti ive yakakodzera kune zvakasiyana-siyana zvekushandisa zvinodhaka.Iro boka re-tert-butyl rinogona kuita seboka rekudzivirira, richibvumira kusunungurwa kusunungurwa kwe rosuvastatin mune dzimwe matishu kana nhengo, dzakadai sechiropa.Iyi nzira inogona kusimbisa kushanda kwemushonga uye kuderedza zvinogona kuitika kuburikidza nekuwedzera kusungirirwa kwayo panzvimbo yakanangidzirwa apo ichideredza kuratidzwa kune zvisingatarisirwi zvinyama.Uyezve, R1.5 inogona kushanda sechinhu chinokosha chemishonga yemishonga mukuwana zvinodhaka uye kubudirira.Chimiro chakaomesesa chekomboni chinopa chikuva chekumwe gadziridzo uye mabviro.Vatsvagiri vanogona kushandisa R1.5 sechinhu chinotungamira kuongorora hukama-chiitwa hukama uye kugadzira analogi matsva ane potency yakawedzerwa, kusarudza, kana akavandudzwa ekurapa profiles.Zvidzidzo zvakadaro zvinogona kuita kuti pave nekuvandudzwa kwemanoveli uye anonyanya kushanda statins kana mamwe cholesterol-anoderedza vamiririri.Pakupedzisira, (+) - (3R,5S), tert-Butyl 7-[4- (4-fluorophenyl) -6-isopropyl. -2-(N-methyl-N-methylsulphonylamino)-pyrimidin-5-yl]-3,5-dihydroxy-6(E)-heptenate (R1.5 kana tert-butyl-rosuvastatin) inobata chivimbiso semushonga wemishonga we kurapwa kwe hyperlipidemia uye chirwere chemwoyo.Chimiro chayo chakasiyana, chakasanganiswa neboka re-tert-butyl, chinogona kupa zvakanakira senge yakagadziridzwa pharmacokinetics, yakanangwa kuendesa zvinodhaka, uye mikana yekuwedzera kugadzirwa kwezvinodhaka.Kumwe kutsvagisa nekusimudzira kunodiwa kuti uongorore zvizere kugona kweR1.5 mumunda wemishonga.