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4- [6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]- piperazine-1-carboxylic acid tert-butyl ester musanganiswa une mukana wekushandisa mukutsvaga kwemishonga nekuvandudzwa kwezvinodhaka.Chimiro chayo chakaoma uye mapoka anoshanda anopa mikana yakasiyana-siyana yekuongorora uye kuongorora maitiro ayo ekurapa.Imwe inogona kushandiswa yekomboni iyi iri mumunda we oncology.Kuvapo kweboka rebromo uye pyrido [2,3-d] pyrimidin moiety inoratidza kuti inogona kuva nekurwisa kenza.Iro boka rebromo rinozivikanwa nekugona kwaro kuvharidzira kukura kweserura uye kukurudzira apoptosis mumasero egomarara.Uyezve, pyrido [2,3-d] pyrimidin scaffold yakabatanidzwa ne-anti-proliferative uye anti-tumor madhara.Nokudaro, chikamu ichi chinogona kuenderera mberi nekudzidza nokuda kwekugona kwayo seanovheti anti-cancer agent.Uyezve, mapoka e-cyclopenyl uye methyl aripo muhutano anoita kuti lipophilic, iyo inogona kuita kuti ikwanise kuyambuka zvipingamupinyi zvehupenyu, zvakadai seropa. -brain chipingamupinyi.Iyi pfuma inovhura mukana wekuishandisa mukugadzirwa kwemishonga inonangana nezvirwere zvepakati tsinga system, senge neurological disorders.Mushonga wacho unogona kuchinjwa kuti uwedzere kusarudzwa kwayo uye simba rinopesana nezvinangwa zvakananga zvinobatanidzwa muzvirwere izvi.Kuwedzera, kuvapo kwepiperazine-1-carboxylic acid tert-butyl ester moiety inoratidza kuti musanganiswa unogona kuva neutility seprodrug.Prodrugs zvigadziriswe zvisingashande zvinogona kushandurwa kuita mafomu anoshanda mukati memuviri.Iro boka re tert-butyl ester rinogona kushanda seboka rinodzivirira, kudzivirira kushandiswa kwemushonga nguva isati yakwana isati yasvika panzvimbo inodiwa yekuita.Kana ichinge yasvika kune inotarirwa tishu kana masero, boka re ester rinogona kuvharwa enzymatically, richibudisa molecule yemishonga inoshandiswa.Uyezve, mutsara we pyridine uye pyrimidine moieties inoratidza kukwanisa kwayo se pharmacophore yekugadzira sarudzo inhibitors kune chaiwo enzymes kana receptors.Izvi zvinogona kubva kinase kusvika kuG protein-coupled receptors, zvichienderana nekugadziriswa kwakaitwa kune yakakosha chimiro.Mushonga uyu unogona kushanda senzvimbo yekutanga yezvidzidzo-zvekuita hukama hwehukama uye kutungamirira optimization kukudziridza ane simba uye anosarudza inhibitors kune zvakananga kurapa zvinangwa. -oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester inoratidza zvingaita munzvimbo dzakasiyana-siyana dzekutsvakurudza kwemishonga.Chimiro chayo chakasiyana uye mapoka anoshanda anogona kuongororwa zvakare kune anti-cancer chiitiko, yepakati tsinga system yekuvandudza zvinodhaka, maitiro eprodrug, uye yakasarudzika enzyme kana receptor inhibition.Kuenderera mberi nekuferefeta uye optimization yemukomboni iyi inogona kutungamira mukuwanikwa kwemaitiro matsva ekurapa ane hunyanzvi hwekuita uye chinangwa chaicho.