Products

Submillimolar concentrations ye cytotoxic bile acids (BAs) inokonzera kufa kwesero kuburikidza neapoptosis.Kune rimwe divi, akati wandei ma cytoprotective BAs akaratidzwa kudzivirira apoptosis mune imwechete yekusangana renji.Zvakadaro, maitiro ayo maBAs anokonzeresa izvi zvinopesana nemasaini maitiro anoramba asina kujeka.Ichi chidzidzo chaive chakanangana nekuona kana cytotoxic uye cytoprotective BAs, pa physiologically active concentrations, inokwanisa kugadzirisa biophysical properties ye lipid membranes, zvingango shandura kuita shanduko muapoptotic chikumbaridzo chemasero.Kusungirirwa kweBAs kune membrane kwakaongororwa kuburikidza nekusiyana kwe fluorescence paramita yeakakodzera maBAs akatorwa.Izvi zvinobva zvapatsanurwa zvine hukama hwepamusoro kune mvura isina kurongeka pane kune iyo cholesterol-inopfumisa mvura yemvura yakarairwa domains.MaBA asina kunyorwa airatidzwa zvakare kuve nenzvimbo yepamusoro pakubatana neiyo lipid membrane.Pamusoro pezvo, kudyidzana kwecytotoxic BAs nemamembrane kwakakonzera kuwedzera membrane, sekubatanidzwa kwakabatanidzwa kubva kuFRET data.Uyezve, zvakaratidzwa kuti cytotoxic BAs dzakakwanisa kukanganisa zvakanyanya kurongeka kwe membrane necholesterol pane physiologically active concentrations yeBA, mhedzisiro isingabatanidzwe nekubvisa cholesterol.Kune rumwe rutivi, cytoprotective bile acids yakanga isina simba pane membrane zvinhu.Izvo zvakagumiswa kuti, zvakacherechedzwa mhedzisiro ye membrane kusimba, iyo apoptotic chiitiko checytotoxic BAs inogona kuve yakabatana neshanduko muplasma membrane musangano (semuenzaniso kuchinjisa lipid domains) kana nekuwedzera mumitochondrial membrane affinity yeapoptotic mapuroteni.