Colonic mabhakitiriya, akaenzanisirwa neBacteroides thetaiotaomicron, anoita basa rinokosha mukuchengetedza hutano hwevanhu nekubatanidza mhuri huru dzeglycoside hydrolases (GHs) kuti dzishandise kudya kwepolysaccharides uye kugamuchira glycans sezvokudya.Kuwedzera kwemhuri yeGH kwakadaro kunoratidzirwa nemhuri ye23 GH92 glycosidases yakavharidzirwa neB. thetaiotaomicron genome.Pano isu tinoratidza kuti aya maalpha-mannosidases anoshanda kuburikidza neayo nzira yekubvisa kushandisa iyo inotambira N-glycans.Iyo yetatu-dimensional chimiro che maviri GH92 mannosidases inotsanangura mhuri yembiri-domain mapuroteni umo catalytic centre iri panzvimbo yedomasi interface, ichipa acid (glutamate) uye base (aspartate) rubatsiro kune hydrolysis muCa (2+) - kutsamira nzira.Iwo matatu-dimensional zvimiro zveGH92s zvakaomarara ane inhibitors zvinopa nzwisiso kune chaiyo, maitiro uye conformational rwendo rwe catalysis.Ca (2+) inoita basa rakakosha mukubatsira kukanganisa mannoside kubva kune yayo yepasi-nyika (4) C (1) chigaro conformation yakananga kumamiriro ekuchinja.
