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1. Chinangwa chechidzidzo ichi chaiva chekugadzira imwe nzira iri nyore ye pharmacokinetic-pharmacodynamic (PK-PD) iyo inogona kuratidza nguva yakakwana yekuchinja kwehuwandu hweplatelet kufanotaura kutanga uye chiyero che thrombocytopenia, iyo inoderedza zvakanyanya kushandiswa kwemishonga. anticancer agent 5-fluorouracil (5-FU), mumakonzo.2. Nhamba dzeplatelet dzakayerwa mumakonzo anotevera kutungamirirwa kwe intravenous kwemaitiro akasiyana-siyana e5-FU kwemazuva 4 kuti awane data yekuongorora kwePK-PD model.Yedu PK-PD modhi yaisanganisira maviri-mukamuri PK modhi, ine makamuri matatu ePD modhi uye gumi ekumisikidza PK-PD modhi paramita.3. Mushure mekurapwa kwe5-FU, nhamba dzeplatelet dzakadzikira zvishoma nezvishoma kusvika padanho re nadir, dzakaratidza kudzokororwa kusvika pamusoro peyero yekutanga isati yadzoserwa kumazinga ekutanga.Nadir platelet kuverenga uye rebounds akasiyana neiyo AUC0-∞ level.Iyo yekupedzisira PK-PD modhi inonyatso ratidza platelet kuverenga data uye yekupedzisira PD paramita yakafungidzirwa nehuchokwadi hwepamusoro.4. Iyi PK-PD modhi uye simulation inogona kumiririra chishandiso chakakosha chekuenzanisa uye kufanotaura nguva yakakwana-yekushandurwa kwehuwandu hwemasero eropa, uye inogona kubatsira mukugadzirwa kwemaitiro ekurapa ne5-FU uye kuongororwa kweakasiyana siyana anticancer agents. izvo zvakaoma kuongorora muvanhu.