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Iyo Tet 5-methylcytosine dioxygenases inokonzeresa DNA demethylation nekugadzira 5-hydroxymethylcytosine uye kuwedzera oxidized zvigadzirwa.Tet1 neTet2 zvinoratidzwa zvakanyanya mumouse pluripotent maseru uye zvakadzikiswa kune akasiyana siyana mumaseru e somatic, asi nzira dzekunyora hadzina kujeka.Pano takatsanangura anosimudzira uye anosimudzira madomasi muTet1 uye Tet2.Mukati me15-kb "superenhancer" yeTet1, kune maviri ekutanga transcript ekutanga masaiti (TSSs) ane akasiyana activation mapatani panguva yekusimudzira.Iyo 6-kb inosimudzira dunhu kumusoro kweiyo distal TSS inoshanda zvakanyanya mumaseru asina ruzivo rwepluripotent, yakazvimiririra inoshuma Tet1 kutaura mune transgenic system, uye nekukurumidza inopinda DNA methylation uye kunyarara pakusiyaniswa mumaseru ane tsika uye epiblast yekuzvarwa.Yechipiri TSS kuzasi, yakabatana neasina kusimba CpG-akapfuma musimudziri, inobatidzwa neanovakidzana anosimudzira mune naive embryonic stem masero (ESCs) uye primed epiblast-seseru (EpiLCs).Tet2 ine CpG chitsuwa p romoter ine pluripotency-yakasununguka chiitiko uye ESC-chaiyo distal intragenic enhancer;iyo yekupedzisira inokurumidza kuderedzwa muEpiLCs.Chidzidzo chedu chinoburitsa nzira dzakasiyana dzekunyorwa kwegwaro paTet1 neTet2 panguva yekuchinja kwesero kwekutanga kusimudzira.Vatori venhau vatsva vanoshandisa Tet1 uye Tet2 cis-regulatory domains vanogona kushandira kusiyanisa shanduko dzakasiyana mumatunhu epluripotent uye pasi peiyo epigenetic misiyano.