Uridine,2′-deoxy-5-ethynyl- Cas:61135-33-9
| Catalog Number | XD90589 |
| Product Name | Uridine, 2'-deoxy-5-ethynyl- |
| CAS | 61135-33-9 |
| Molecular Formula | C11H12N2O5 |
| Molecular Weight | 252.23 |
| Storage Details | -20°C |
| Harmonised Tariff Code | 29349990 |
Chigadzirwa Specification
| Chitarisiko | Ichena kusvika kuOrange kusvika kuGreen powder kuita crystal |
| Assay | ≥99% |
Ichi chidzidzo chakaitwa kuti chiongorore kuwedzera kwemaitiro emiriwo soy peptides pane vakuru stem masero (ASCs) mukushaikwa kweserum uye nzira dzadzo dzekuita.Kuwedzera kweadipose tissue-yakatorwa mesenchymal stem masero (ADSCs) uye tambo yeropa-yakatorwa mesenchymal stem masero (CB-MSCs) akabatwa ne soy peptides akawanikwa achiwedzera zvakanyanya pa3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide uye Click-iT 5-ethynyl-2'-deoxyuridine flow cytometry assay.Pamusoro pezvo, soy peptides yakatungamira kune stepwise phosphorylation yep44/42 MAPK (ERK), mammalian chinangwa cherapamycin (mTOR), p70 S6 kinase, S6 ribosomal protein (S6RP) uye eukaryotic initiation factor 4E (eIF4E) muADSCs.Uyezve, kuongororwa kwehuwandu hwema cytokines kwakaratidza kuti kugadzirwa kwekushandura kukura factor-beta1 (TGF-β1), vascular endothelial growth factor uye interleukin-6 yakawedzera zvakanyanya mukupindura kurapwa ne soy peptides mune zvose ADSCs uye CB-MSCs.Saizvozvowo, soy peptide-induced phosphorylation yeERK/mTOR/S6RP/eIF4E nzira yakavharwa mukupindura pretreatment nePD98059, imwe ERK inhibitor.Uyezve, inhibition yeTGF-β1 kuburikidza nePD98059 pretreatment uye kuderera kunotevedzana mukuwedzera kweADSC kwakaratidza kuti TGF-β1 induces phosphorylation ye mTOR/S6RP/eIF4E.Pamwe chete, mhedzisiro yeongororo iyi inoratidza kuti kugadzirwa kunoenderana neERK kweTGF-β1 kunobata basa rakakosha mukuwanda kwe soya peptide-induced ADSCs pasi pemamiriro asina serum.Copyright © 2012 Elsevier Inc. All rights reserved.
