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Fluorouracil antineoplastic mishonga inogadzirwa nefluorouracil.Iyo thymidine phosphorylase iripo mune bundu tishu inoshanda pairi kuishandura kuita fluorochemicalbook uracil mubundu, nekudaro ichiita anti-bundu mhedzisiro.Yayo anti-tumor chaiyo yakasimba, uye huturu hwayo hwakaderera.Clinically inoshandiswa kwegomarara remudumbu, colorectal cancer, gomarara rezamu, chiyero chekuregererwa chinogona kusvika kupfuura 30%.

Kushanda kwe systemic chemotherapy yekuparadzira peritoneal cancer yemudumbu haisati yanyatsojeka.Kushanda kwevhiki nevhiki paclitaxel pamwe chete nedoxifluridine (5'-DFUR) muvarwere vekenza yemudumbu vane ascites yakaipa yakaongororwa.Kurapa kwaisanganisira paclitaxel intravenously (iv) inoshandiswa pa80 mg / m (2) pamazuva 1, 8 uye 15 masvondo ose e4, uye doxifluridine yaipiwa nemuromo pa 533 mg / m (2) mumazuva 1-5 vhiki imwe neimwe.Chiyero chekupindura kwevarwere vane ascites chakatemerwa zvichienderana neJapan Classification yeGastric Carcinoma.Uyewo, kukanganiswa kwepaclitaxel mu ascites kwakayerwa.Varwere makumi maviri nevana vakaongororwa.Nhamba yekupindura (RR) yaiva 41.7%, kusanganisira kuregererwa kwakakwana (CR) uye chikamu chekuregererwa (PR) mu4 uye 6 varwere, maererano.Iko kusungirirwa kwepaclitaxel mu ascites kwakachengetwa pakati pe0.01 μM uye 0.05 μM kusvika maawa makumi manomwe nemaviri.Kupona kwepakati pese (OS) kwaive mazuva 215, uye 1-gore rekupona raive 29.2%.Hapana huturu hwakanyanya hwakaonekwa.Weekly paclitaxel pamwe chete nedoxifluridine inoshanda kune varwere vegomarara remudumbu vane malignant ascites ine muchetura unogamuchirwa.