5-Methylphenazinium methosulfate Cas: 299-11-6 99% Yakasvibirira yakasvibirira kusvika kuhupfu hwakasvibirira
| Catalog Number | XD90224 |
| Product Name | 5-Methylphenazinium methosulfate |
| CAS | 299-11-6 |
| Molecular Formula | C14H14N2O4S |
| Molecular Weight | 306.337 |
| Storage Details | -15 kusvika -20 °C |
| Harmonised Tariff Code | 29339980 |
Chigadzirwa Specification
| Melting Point | 158-160 °C (Zvita)(lit.) |
| Assay | 99% |
| Form | Solid |
| Chitarisiko | Upfu hwakasvibira kusvika kubrown |
Iyo n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) uye docosahexaenoic acid (DHA) yakaratidzwa kuwedzera mhedzisiro yemishonga yekurapa chemotherapeutic muzvidzidzo zvekiriniki mune varwere vekenza uye kukurudzira apoptotic tumor cell death in vitro.Kusvika parizvino, EPA neDHA hazvina kumbobvira zvaongororwa mune akawanda myeloma (MM).Masero myeloma emunhu (L363, OPM-1, OPM-2 uye U266) uye masero eropa emononuclear eropa akaiswa pachena kuEPA neDHA, uye mhedzisiro pamitochondrial basa uye apoptosis, caspase-3 activation, gene expression uye toxicity yezvinodhaka zvakayerwa.Kuratidzira kuEPA neDHA kwakakonzera apoptosis uye kuwedzera kunzwa kune bortezomib muMM masero.Zvakakosha, hazvina kukanganisa kushanda kweakajairika peripheral mononuclear masero emunhu.Messenger RNA kutaura arrays yakaratidza kuti EPA neDHA modulated genes inobatanidzwa munzira dzakawanda dzekusaina dzinosanganisira nuclear factor (NF) κB, Notch, Hedgehog, oxidative stress uye Wnt.EPA uye DHA yakadzivisa NFκB basa uye yakakonzera apo ptosis kuburikidza nemitochondrial perturbation uye caspase-3 activation.Kudzidza kwedu kunoratidza kuti EPA neDHA inokurudzira yakasarudzika cytotoxic mhedzisiro muMM uye kuwedzera sensitivity kune bortezomib uye inodaidzira kuti iwedzere kuongororwa mune inogona kushandiswa kweaya n-3 polyunsaturated fatty acids mukurapa kweMM.
