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Chinangwa chechidzidzo ichi chaive chekuenzanisa kushanda kwevalproate inopesana nehaloperidol mukuderedza danho rekushungurudzika muvarwere vakabatwa mudhipatimendi rekukurumidzira.Takapa 80 varwere vakanyanya kunetseka kuti vagamuchire intravenous sodium valproate (20 mg/kg) kana intramuscular haloperidol (5 mg/1 ml).Kushungurudzika kwakayerwa pakutanga uye 30 min mushure mejojo ​​yekutanga uchishandisa Agitation-Calmness Evaluation Scale (ACES), Positive uye Negative Syndrome Scale-Excited Component subscale, uye Agitated Behavior Scale.Kune varwere ve80 vakabatwa ne sodium valproate, zvinoreva ± SD dosage yaiva 1541.5 ± 286 mg (range 940-2400).Zvinorehwa postintervention ACES zvibodzwa kubva pakutanga kusvika ku30 min mushure mejekiseni yezvinodhaka yaive 4.73 (SD = 1.93) yeboka revalproate uye 5.45 (SD = 2.09) yeboka rehaloperidol (P = 0.028).Hapana misiyano yakakosha yakacherechedzwa maererano neanoreva shanduko 30 min mushure mekupindira kune maviri ekuwedzera mazero ekushungurudza.Chikamu chikuru chevarwere vari muboka rehaloperidol vakawana sedation yakasimba (36.2%, P <0.001) uye zviratidzo zve extrapyramidal (8.7%, P = 0.007) zvichienzaniswa neboka revalproate (2.5% nokuda kwekudyisa zvakanyanya, pasina murwere kune extrapyramidal zviratidzo).Zvakawanikwa zvinoratidza kuti muchirongwa chekiriniki yekumisikidza yekukurumidzira psychiatry, intravenous valproate inoshanda se haloperidol mukuderedza kushushikana, ine kuchengetedzwa kuri nani.