![Bis[2-Hydroxyethyl] imino Tris-(Hydroxymethyl)-methane Cas: 6976-37-0 99% Featured Image](http://cdn.globalso.com/xdbiochems/6976-37-0.jpg)
Bis[2-Hydroxyethyl] imino Tris-(Hydroxymethyl)-methane Cas: 6976-37-0 99%
| Catalog Number | XD90111 |
| Product Name | BIS-TRIS (Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane) |
| CAS | 6976-37-0 |
| Molecular Formula | C8H20NO5 |
| Molecular Weight | 210.2476 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 2922190090 |
Chigadzirwa Specification
| Heavy metals | <10ppm |
| Residue paIgnition | <0.1% |
| Pka | 6.3-6.7 |
| Chitarisiko | White Crystalline Powder |
| Solubility (1M muH20) | Zvakajeka uye Zvakakwana |
| pH (1M muH2O) | 9.0-11.0 |
| Kunyorova (LOD) | 1.0% max. |
| Assay (Titration pane yakaoma base) | 99.0% min. |
Buffer, inoshandiswa pakuona creatine-creatinase;zvakare inoshandiswa pakudzivirira kunoshanda kwe hemoglobin muchando-kuomesa;catholyte, inoshandiswa muIEF/2-D gel electrophoresis.
Glial cell line-derived neurotrophic factor (GDNF) inhibitor yakasimba ye ethanol kushandiswa uye kudzokazve, uye GDNF heterozygous knockout mice inoratidza yakawedzera mubairo senitivity kune ethanol uye inopedza ethanol yakawanda mushure menguva yekurega kupfuura mhuka dzesango.Pano, takaedza kana ethanol inoshandura GDNF kutaura mu ventral tegmental area (VTA; GDNF's site of action) uye / kana nucleus accumbens (NAc; iyo huru yeGDNF), uye kana zvakadaro, sarudza basa rekukura kwekupedzisira. mukutonga kwekushandisa ethanol.Systemic administration ye ethanol yakawedzera GDNF kutaura uye mapuroteni mazinga muVTA, asi kwete NAc.Uyezve, mazinga eGDNF akakwidziridzwa mushure memusangano wekunwa ethanol mumakonzo akadya ethanol mune inopindirana-yekuwana mabhodhoro maviri-mabhodhoro maitiro kwevhiki 1, asi kwete mavhiki manomwe.Kushayikwa kunotevera mavhiki e7 ekunyanyisa ethanol kudya kwakaderedza mazinga eGDNF, nepo ethanol shoma yekunwa kunwa nguva inotevera kushayikwa kwakagadziriswa GDNF kutaura.Zvinonyanya kukosha, kugogodza kweGDNF mukati meVTA uchishandisa adenovirus ichiratidza short hairpin RNA yakafambisa kuwedzera kwekunwa ethanol nemakonzo ethanol-naïve, asi kwete nemakonzo ane nhoroondo yekunyanya kushandiswa kwe ethanol.Migumisiro iyi inoratidza kuti panguva yezviitiko zvekutanga ethanol-kunwa, GDNF muVTA inowedzerwa uye inodzivirira pakusimudzirwa kwekunyanya kunwa ethanol.Nekudaro, iyo yekukura chinhu chekudzivirira mhinduro kune ethanol inoputsika mushure menguva yakareba yakawandisa ethanol kutora uye kubvisa, zvichikonzera kuramba, yakawandisa ethanol kushandiswa.
