Acriflavine, neutral Cas: 8048-52-0 Orange kusvika kutsvuku kusvika kutsvuku-brown poda
| Catalog Number | XD90521 |
| Product Name | Acriflavine, isina kwayakarerekera |
| CAS | 8048-52-0 |
| Molecular Formula | C14H14ClN3 |
| Molecular Weight | 259.73 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 38249993 |
Chigadzirwa Specification
| Chitarisiko | Orange kusvika kutsvuku kusvika kuhupfu hutsvuku |
| Assay | 99% |
| AS | 10ppm max |
| Kurasika paKuomesa | 8% max |
| Mvura isinganyunguriki | 0.5% max |
| Sulfated ash | 3.5% max |
| Kuongororwa kweklorini yemukati yakaomeswa @ 105 Deg C kwemaawa maviri | 13.3 - 15.8% |
Mishonga yakawanda yegomarara inotadza kubvisa mamota, izvo zvinoita kuti pave nekusagadzikana kwemishonga uye kudzoka kwechirwere.Iyo Hedgehog kusaina inoita basa rakakosha panguva yekukura embryonic, asi zvakare inobatanidzwa mukukura kwegomarara, kufambira mberi, uye metastasis.Iyo Hedgehog receptor Patched (Ptc) iHedgehog inosaina tarisiro jini iyo yakanyanyisa kuwedzeredza mumaseru mazhinji egomarara.Pano, isu tinoratidza chinongedzo pakati pePtc uye kuramba chemotherapy, uye inopa ruzivo rutsva muPtc basa.Ptc inocheneswa kubva muplasma membrane pakusangana nehedgehog yayo, kana pakurapwa kwemasero ane Hedgehog inosaina anopikisa cyclopamine.Muzviitiko zvese izvi, mushure mekuiswa kwemasero ane doxorubicin, chemotherapeutic agent iyo inoshandiswa kukiriniki manejimendi yekenza inodzoka, takaona kudzivirirwa kwekubuda kwedoxorubicin kubva kuHedgehog-inopindura fibroblasts, uye kuwedzera kwedoxorubicin kuunganidzwa mukenza mbiri dzakasiyana. mitsara yesero inozivikanwa kuratidza aber rant mazinga eHedgehog kusaina zvikamu.Tichishandisa heterologous expression system, isu takanyatsoratidza kuti kutaura kwePtc yemunhu kwakapa kuramba kukura kwekudzivirira nemishonga yakati wandei kubva kune chemotherapeutic agents senge doxorubicin, methotrexate, temozolomide, uye 5-fluorouracil.Kupokana kune doxorubicin yakabatana nePtc basa, sezvakaratidzwa kushandisa shanduko kubva kuvarwere veGorlin's syndrome umo Ptc-mediated effect paHedgehog signing inorasika.Mhedzisiro yedu inoratidza kuti Ptc inobatanidzwa mukuderera kwezvinodhaka uye kuramba kwezvinodhaka zvakawanda, uye zvinopa zano kuti Ptc inobatsira mukurwisa chemotherapy kwemasero egomarara.
