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Neuroblastoma, gomarara retsitsi retsinga dzetsinga, ndiro rinonyanya kuoneka extracranial solid bundu muvana.MYCN amplification uye yakawedzera BDNF/TrkB siginecha zvinhu zvemamota ane njodzi huru;zvakadaro, chete ˜25% yemamota akaipa anoratidza maitiro aya.Nekudaro, kuzivikanwa kwemamwe ma biomarker uye kurapa zvinangwa zvakakosha.Se aminoacylase 1 (ACY1), amino acid deacetylase, is putative bundu suppressor mudiki cell lung uye renal cell carcinomas, takaongorora kana iyo kana dzimwe nhengo dzemhuri aspartoacylase (ASPA, aminoacylase 2) kana aminoacylase 3 (ACY3) inogona kushanda. basa rakafanana mune neuroblastoma.Aminoacylase kutaura kwakaongororwa muTrkB-positive, MYCN-amplified (SMS-KCNR uye SK-N-BE) uye TrkB-negative, non-MYCN-amplified (SK-N-AS, SK-N-SH, SH-SY5Y uye SH-EP) neuroblastoma cell mitsara.Imwe neimwe aminoacylase yairatidza yakasarudzika nzvimbo yenzvimbo (kureva, cytosolic ACY1, membrane-yakabatana ASPA uye nuclear ACY3).Apo masero eSK-N-SH akabatwa neineural differentiation agents (eg, retinoic acid uye cAMP) munhau dzine 10% serum, ACY1 ndiyo chete aminoacylase iyo kutaura kwakagadziriswa.ASPA yainyanya kuratidzwa muSH-EP masero e glial sublineage.ACY3 yainyanya kuratidzwa muTrkB-positive, MYCN-yakawedzera mitsetse.Ese matatu aminoacylases akaratidzirwa mune yakajairwa adrenal gland yemunhu, yakajairika saiti yeneuroblastoma kwakabva, asi chete ACY1 uye ACY3 yakaratidza detectable expression in primary neuroblastoma tumor.Bioinformatics data mining yekupona kweKaplan-Meier yakaratidza kuti yakakwira ACY3 kutaura kune hukama nehurombo hwekufungidzira, nepo kushomeka kweACY1 kana ASPA kwakabatana nekusaziva fungidziro.Iyi data inoratidza kuti aminoacylase kutaura kwakakanganiswa mu neuroblastoma