Products

Hushasha hwekurwisa utachiona hwakasanganiswa nekushaikwa kwemishonga mitsva inorwisa utachiona hwawedzera kufarira mukugadzirwa kweantimicrobial peptides (AMPs) sezvitsva zvekurapa.Muchidzidzo ichi, takaongorora maitiro eantimicrobial maviri mapfupi ekugadzira peptides, anoti, RRIKA neRR.Aya mapeptide airatidzira ane simba antimicrobial chiitiko kurwisa Staphylococcus aureus, uye mhedzisiro yavo yeantimicrobial yakasimudzirwa zvakanyanya nekuwedzera matatu amino acids muC terminus, izvo zvakazowedzera amphipathicity, hydrophobicity, uye net charge.Uyezve, RRIKA neRR zvakaratidza hutachiona hunokosha uye hunokurumidza kurwisa Staphylococcus isolates yekiriniki uye isingaurayiwi nemishonga, kusanganisira methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate S. aureus (VISA), vancomycin-resistant S. aureus (VRSA) , linezolid-resistant S. aureus, uye methicillin-resistant Staphylococcus epidermidis.Kusiyana neakawanda echisikigo AMPs, RRIKA neRR vakachengeta t mugari wenhaka pamberi pehupo hwehupenyu hweNaCl uye MgCl2.Ose ari maviri RRIKA neRR akasimudzira kuurayiwa kwe lysostaphin kanopfuura chiuru uye kwakabvisa MRSA neVRSA kuzvitsaura mukati memaminitsi makumi maviri.Uyezve, mapeptide akaunzwa aive epamusoro mukuderedza adherent biofilms yeS. aureus uye S. epidermidis zvichienzaniswa nemhedzisiro neyakajairwa mishonga inorwisa mabhakitiriya.Zvatakawana zvinoratidza kuti staphylocidal mhedzisiro yepeptides yedu yaive kuburikidza nepermeabilization yebhakitiriya membrane, zvichikonzera kudonha kweiyo cytoplasmic zvirimo uye sero kufa.Uyezve, peptides yakanga isiri muchetura kumasero eHeLa pa4- kusvika ku8-peta maitiro avo emishonga inorwisa mabhakitiriya.Izvo zvine simba uye zvine munyu-zvisinganzwe antimicrobial zviitiko zvemapeptide zvinopa anoyevedza mukwikwidzi wekurapa wekurapwa kweakawanda-resistant zvinodhaka S. aureus.