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Gumi neshanu platinum(II)-based metallointercalators akagadzirwa anoshandisa inotsiva 1,10-phenanthroline (phen) ligands, kusanganisira 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) uye dipyrido[3,2-d :2',3'-f]quinoxaline (dpq), and achiral ethylenediamine (en) and the chiral ancillary ligands 1S,2S-diaminocyclohexane (S,S-dach) uye 1R,2R-diaminocyclohexane (R,R-dach) .Cytotoxicity yavo muL1210 murine leukemia cell line yakatemwa kushandisa kukura inhibition assays.Akanyanya cytotoxic metal complexes ndeaya ane S,S-dach ancillary ligands uye 5-CH3-phen intercalating ligands.Imwe metallointercalator [Pt(5-CH3-phen)(S,S-dach)]Cl2 (5MESS), inoratidza kuwedzera kwe 5-10-fold in cytotoxicity kana ichienzaniswa nekiriniki mumiririri cisplatin.Kubva kuDNA inosunga zviyedzo zvinoita sekunge pasina mutsauko wakakura pakati pechero simbi yakaoma, zvichiratidza kuti hapana DNA inosunga hukama kana nzira yekusunga / DNA adduct yakaumbwa ndiyo chete inogadzirisa cytotoxicity yemhuri iyi yeplatinamu (II) -yakavakirwa. metallointercalators.