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1.Kuongorora kana adenosine diphosphate (ADP) -derived adenosine inogona kudzivisa platelet aggregation, kunyanya pamberi peP2Y₁₂ antagonist, apo migumisiro yeADP paP2Y₁₂ receptor yaizodziviswa.Platelet aggregation yakayerwa mukupindura kune activator receptor peptide ne platelet counting mu platelet-rich plasma (PRP) uye ropa rose pamberi peADP uye P2Y₁₂ vanopikisa cangrelor, prasugrel active metabolite, uye ticagrelor.Muhupo hweP2Y₁₂ anopikisa, preincubation yePRP neADP inhibited aggregation;mhedzisiro iyi yakabviswa neadenosine deaminase.Hapana kudziviswa kwekuunganidza kwakaitika muropa rose kunze kwekunge dipyridamole yakawedzerwa kuti inhibit adenosine kupinda mu erythrocytes.Migumisiro yeADP muPRP uye ropa rose rakadzokororwa uchishandisa adenosine uye yakabatana zvakananga nekuchinja kwekampu (yakaongororwa ne vasodilator-stimulated phosphoprotein phosphorylation).Migumisiro yose yakanga yakafanana pasinei neP2Y₁₂ ant agonist yakashandiswa.ADP inhibits platelet aggregation pamberi peP2Y₁₂ antagonist kuburikidza nekushandurwa kuadenosine.Inhibition inowanikwa muPRP asi kwete muropa rose kunze kwekunge adenosine uptake inodziviswa.Hapana wevapikisi veP2Y₁₂ vakadzidza vakadzokorora mhedzisiro ye dipyridamole mune zviyedzo zvakaitwa.

2.ADP inoonekwa seine platelet agonist isina simba nekuda kwemhinduro shoma yekuunganidza iyo inokonzera in vitro pa physiological concentrations of extracellular Ca (2+) [(Ca (2+) ) (o) ].Kudzikisa [Ca(2+) ](o) zvinokatyamadza zvinosimudzira ADP-evoked aggregation, mhedzisiro yakanzi inokonzerwa nekuwedzerwa thromboxane A(2) kugadzirwa.Ichi chidzidzo chakaongorora basa re ectonucleotidases mu [Ca (2+)] (o) -kutsamira kweplatelet activation.Kuderedza [Ca (2+) ] (o) kubva ku millimolar kusvika ku micromolar mazinga akashandurwa ADP (10 μmol/l) -akabvisa platelet aggregation kubva kune yenguva pfupi kusvika kune yakagadzikana mhinduro mune zvose zviri zviviri platelet-rich plasma uye yakasukwa yakasukwa.Kuvharisa thromboxane A(2) kugadzirwa ne aspirin kwainge kusina simba pane izvi [Ca(2+) ](o) -dependence.Kudzivirirwa kwekuora kweADP kwakabvisa misiyano pakati pepasi uye physiological [Ca (2+)] (o) zvichiita kuti pave nekubatana kwakasimba uye kwakasimba mumamiriro ose maviri.Zviyero zve extracellular ADP zvakaratidza kuderedzwa kuderera mune zvose plasma uye apyrase-ine g saline pa micromolar ichienzaniswa ne millimolar [Ca (2+)] (o) .Sezvakambotaurwa kare, thromboxane A (2) chizvarwa chakawedzerwa pasi [Ca (2+)] (o) , zvisinei izvi zvakanga zvakasununguka pane ectonucleotidase chiitiko (.) P2Y receptor antagonists cangrelor uye MRS2179 yakaratidza kukosha kweP2Y (12) receptors yeADP-evoked aggregation, ine basa diki reP2Y(1) .Mukupedzisa, Ca (2+) -dependent ectonucleotidase basa chinhu chikuru chinogadzirisa huwandu hweplatelet aggregation kuADP uye inofanira kudzorwa muzvidzidzo zveP2Y receptor activation.