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Mapoka matatu ehurume dzechirume cynomolgus monkey (Macaca fascicularis) dzakaratidzwa kune 200 micrograms / m3 ammonium hexachloroplatinate [(NH4) 2PtCl6], 200 micrograms (NH4) 2PtCl6 panguva imwe chete ne1 ppm ozone (O3), kana kuO3 1 chete.Mhuka idzi dzakafumurwa nekufemerwa kwe6h pazuva, mazuva mashanu pasvondo kwe12 wk.Dhizaini yekuyedza yaisanganisira methacholine preexposure uye Na2PtCl6 bronchoprovocation dambudziko kuongororwa, Na2PtCl6 chikumbaridzo cheganda bvunzo, uye sera yekuongorora masoja ekudzivirira chirwere.Vhiki mbiri mushure mekuratidzwa kwe12-wk, aya ma indices akaongororwazve.Baseline pulmonary function haina kunyanya kukanganiswa nemaitiro ekutsvaga;zvisinei, kusanganiswa kwekutsvaga kuO3 uye (NH4) 2PtCl6 zvakanyanya kuderedza kuwanda kweplatinum (Pt) munyu uye methacholine inodiwa kuti iwedzere kuenzana kwepulmonary flow resistance (RL) 200% (EC200 RL).Ozone kana Pt exposure chete yakanga isina mhedzisiro yakakosha pane aya ma paramita.Platinum uye methacholine EC200 RL tsika dzaive dzakanyatsoenderana kune ese Pt-akafumurwa mapoka mushure mekuratidzwa.Iyi data yakaratidza kuti kusanganiswa kweO3 nePt kuratidzwa kwakanyanya kuwedzera chaiyo (Pt) uye nonspecific (methacholine) bronchial hyperreactivity kakawanda kupfuura kuratidzwa kune O3 kana Pt munyu chete.Yakasanganiswa O3 pamwe nePt kuratidzwa zvakare kunowedzera zvakanyanya kuitika kweiyo yakanaka Pt ganda bvunzo kana ichienzaniswa nemamwe mapoka ekuratidzira.Zvakafanana neruzivo rwevanhu, radioallergosorbent test (RAST) yePt-specific antibodies yakanga isinganzwisisike sekuongororwa kweganda kwakananga mukuona vanhu vanorwara.