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Kufutisa, Type 2 chirwere cheshuga uye hyperlipidemia zvinowanzogara pamwe chete uye zvinosanganiswa nekuwedzera zvakanyanya kurwara uye kufa.Kushandiswa kwekabhohydrate yakanatswa uye kunyanya fructose yakawedzera zvakanyanya mumakore achangopfuura uye yakaenzana nekuwedzera kwehuwandu hwekufutisa uye chirwere cheshuga.Zvidzidzo zvevanhu nemhuka zvakaratidza kuti kudya kwakanyanya kwefructose kunoenderana nekuwedzera dyslipidemia, insulin kuramba, uye hypertension.Metabolism yefructose inoitika zvakanyanya muchiropa uye yakakwira fructose flux inotungamira kune yakawedzera hepatic triglyceride accumulation (hepatic steatosis).Izvi zvinoguma nekukanganiswa kweglucose uye lipid metabolism uye kuwedzera proinflammatory cytokine kutaura.Pano tinoratidza kuti fructose inoshandura glucose-inosimudzira kutaura kweacetyl CoA carboxylase (ACC), pSer hormone sensitive lipase (pSerHSL) uye adipose triglyceride lipase (ATGL) muhepatic HepG2 kana primary hepatic cell tsika in vitro.Izvi zvaibatanidzwa nekuwedzera de novo triglyceride synthesis in vitro uye hepatic steatosis in vivo mufructose-versus glucose-fed uye standard-diet fed mice.Zvidzidzo izvi zvinopa ruzivo rutsva mumaitiro anosanganisirwa mufructose-mediated hepatic hypertriglyceridemia uye kuona fructose-uptake sechinhu chitsva chinogona kurapa chinangwa chezvirwere zvine lipid.