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Mucoadhesive mafirimu ane curcumin-akatakura nanoparticles akagadzirwa, aine chinangwa chekuwedzera nguva yekugara yefomu yedose mumuromo wemuromo uye kuwedzera kunwa kwezvinodhaka kuburikidza nebuccal mucosa.Mafirimu akagadzirwa nenzira yekukanda mushure mekuiswa kwe curcumin-yakatakura chitosan-yakavharwa polycaprolactone nanoparticles mupurasitiki chitosan mhinduro.Yakasiyana molar masasi emucoadhesive polysaccharide chitosan uye kuomeswa kweplasticizer glycerol yakashandiswa kugadzirisa mamiriro ekugadzirira.Mafirimu akawanikwa achishandisa epakati uye akakwira molar mass chitosan akawanikwa aine homogeneous uye anochinjika.Curcumin-yakatakura nanoparticles yakagoverwa zvakafanana pamusoro pefirimu pamusoro, sezvinoratidzwa neatomu simba microscopy uye yakakwirira-resolution field-emission gun scanning electron microscopy (FEG-SEM) mifananidzo.Ongororo yezvikamu zvemuchinjiro wemufirimu uchishandisa FEG-SEM inoratidza kuvepo kwenanoparticles mukati memafirimu.Pamusoro pezvo, mafirimu airatidza kuve ane mwero wakanaka we hydration mune yakateedzerwa saliva solution, ichiratidza kunyanyisa kuzvimba kunosvika 80% uye in vitro yakarebesa-inodzorwa kuendesa curcumin.Migumisiro iyi inoratidza kuti mucoadhesive mafirimu ane nanoparticles anopa nzira inovimbisa ye buccal delivery ye curcumin, iyo inogona kunyanya kubatsira mukurapa periodontal zvirwere zvinoda kuchengetedzwa kwezvinodhaka.© 2014 Wiley Periodicals, Inc. uye American Pharmacists Association.