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Intestinal bacterial metabolite yeginseng protopanaxadiol saponin, 20-O-(β-D-glucopyranosyl) -20(S) -protopanaxadiol (compound K), yakanzi inokonzera apoptosis mumhando dzakasiyana dzekenza masero.Zvisinei, nzira chaidzo dzakakonzerwa nekomboni K mumasero emunhu hepatocellular carcinoma (HCC) dzinoramba dzisina kujeka.Kuti titarise nzira dzeapoptotic dzinogona kuitika, takaongorora iyo anticancer mhedzisiro yekomboni K muMHCC97-H.MTT assay yakaratidza kuti kompani K yakadzivisa kupararira kweMHCC97-H masero ane huturu hushoma mumasero ehepatoma.Kufambira mberi kwesero uye kusvibiswa kwesero kwakaratidza kuwedzera kweapoptotic sub-G1 chikamu.Kurapa kweMHCC97-H nekomboni K kwakakonzerawo kuderedzwa kwemitochondrial membrane inogona (Δψm) uye DNA kukuvara.Kumwe kuongorora kwakaratidza kuti komputa K yakasimudzira Fas, FasL, Bax/Bcl-2 chiyero uye yakaderedzwa pro-caspase-9, pro-caspase-3 nenzira inotsamira mudosi, uye yakadzivisawo Akt phosphorylation.Mhedzisiro iyi inoratidza kuti komputa K inodzivirira zvakanyanya kuwanda kwesero uye inoita kuti apoptosis muMHCC97-H masero kuburikidza neFas- uye mitochondria-mediated caspase-inotsamira nzira mumaseru eHCC.