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Calculated globulin (total protein - albumin) inowanzoongororwa sechikamu chechiropa basa rekuongorora purogiramu mune zvose zvekutanga uye zvechipiri kutarisirwa uye inotarisa serum globulin concentration, iyo immunoglobulins inhengo huru.Iko kushandiswa kukuru kusvika ikozvino kweakaverengerwa globulin ndeyekuona paraprotein kana mwero wakakwira.Chidzidzo ichi chakaongorora kugona kushandisa mazinga akaderera eglobulin akaverengerwa kuona kushomeka kwemasoja ekudzivirira chirwere.Serum samples ine yakaverengerwa globulin cut-off <18 g/l zvichibva pamhedzisiro yeongororo yekutyaira yakaunganidzwa kubva kuzvipatara zvipfumbamwe muWales mukati memwedzi gumi nemaviri.Ruzivo rwekukumbira rusingazivikanwe rwakawanikwa uye sampuli dzakaedzwa mazinga e immunoglobulin, serum electrophoresis uye, kana zvakakodzera, immunofixation.Imwe nzira yekuenzanisa yekuyera albumin uchishandisa bromocresol yegirini uye bromocresol yepepuru yakaitwa.Zvikamu makumi masere nepfumbamwe kubva muzana (737 kubva pa826) masampuli aive ne immunoglobulin (Ig) G level ye <6 g/l vachishandisa nzira yebromocresol yegirini ine kucheka-kubuda kwe<18 g/l, uye 56% (459) vaive nayo. IgG ye <4 g/l.Varwere vane zvose zvechipiri uye zvekutanga zvekudzivirira antibody zvakawanikwa uye serum electrophoresis uye immunofixation yakaratidza kuti 1 · 2% (10) yakanga isati yamboona maparaprotein maduku akabatanidzwa neimmune-paresis.Ichishandisa bromocresol yepepuru, 74% yemasamples aive neIgG ye<6 g/l vachishandisa cut-off ye<23 g/l.Kuongorora uchishandisa yakaverengerwa globulin ine yakatsanangurwa kucheka-kubvisa kukosha kunoona zvese zvekutanga uye zvechipiri antibody kushomeka uye maparaprotein matsva ane chekuita neimmune-paresis.Yakachipa, inowanikwa zvakanyanya uye isingashandiswe.Varwere vanoshaya maAntibody vakawanikwa vachishandisa ruzivo kubva kwakaverengerwa globulin kukosha, kupfupisa kuongororwa kunonoka uye nguva yekurapwa ne immunoglobulin replacement therapy.