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Cystic fibrosis chirwere chemajini umo mukosi usina kujairika mumapapu unobatanidzwa nekusabatwa nechirwere chisingaperi.Pulmonary exacerbations ndipo apo zviratidzo zvehutachiona zvinonyanya kusimba.Mishonga inorwisa mabhakitiriya chinhu chakakosha chekurapa kwekuwedzeredza uye maantibioti akafemeswa anogona kushandiswa ari ega kana pamwe chete nemishonga inonwiwa kuitira kuwedzera kwakadzikama kana nemishonga inorwisa mabhakitiriya kune hutachiona hwakanyanya.Inhaled maantibioti haakonzeri mhedzisiro yakaipa senge intravenous antibiotics uye inogona kuratidza imwe nzira muvanhu vasina mukana wekupinda mutsinga dzavo.Kuziva kana kurapwa kwepulmonary exacerbations ne inhaled antibiotics muvanhu vane cystic fibrosis inovandudza hupenyu hwavo, inoderedza nguva yekuenda. chikoro kana basa uye inovandudza kurarama kwavo kwenguva refu.Takatsvaga ClinicalTrials.gov uye Australia neNew Zealand Clinical Trials Registry yemiedzo yakakodzera.Zuva rekupedzisira kutsvaga: 15 Kurume 2012Tatsvaga zvakare muCochrane Cystic Fibrosis G roup's Cystic Fibrosis Trials Register.Zuva rekutsvaga kwekupedzisira: 01 June 2012. Randomised controlled trials muvanhu vane cystic fibrosis vane pulmonary exacerbation umo kurapwa nemishonga inorwisa mabhakitiriya yakafananidzwa ne placebo, kurapa kwakajairika kana imwe antibiotic inofemerwa pakati pevhiki imwe ne4. Vanyori vaviri vekuongorora vakazvimiririra. yakasarudzwa miedzo yakakodzera, yakaongorora njodzi yekusarura muyedzo yega yega uye yakabudiswa data.Vanyori vezviedzo zvakabatanidzwa vakabatwa kuti vawane mamwe mashoko.Miyedzo mitanhatu nevatori vechikamu 208 yakabatanidzwa mukuongorora.Miedzo yaive yakasiyana mukugadzira uye kupindira (zvisinei, zvese zvaisanganisira miedzo yakaenzaniswa inhaled inopesana ne intravenous antibiotic regimens).Njodzi yekurerekera yaive yakaoma kuongorora mumiyedzo mizhinji.Migumisiro yakanga isati yanyatsorondedzerwa uye data shoma chete yakanga iripo yekuongorora.Miedzo ina yakashuma mimwe mibairo yekumanikidzwa kupera simba pasekondi imwe uye haina kuwana misiyano yakakosha pakati peiyo inhaled antibiotic uye kuenzanisa kupindira kwemwanakomana.Mune miviri yezviedzo izvi uchishandisa 300 mg ye inhaled tobramycin, kuchinja kwekumanikidzirwa kwekuputika kwevhoriyamu pane imwe sekondi yakafanana ne intravenous tobramycin;uye mune imwe muedzo nguva kusvikira kuwedzera kunotevera kwakanga kusina kusiyana.Hapana migumisiro yakaipa inokosha yakataurwa.Kune humbowo hushoma hunobatsira hwepamusoro-soro hwekutonga kushanda kwemishonga inorwisa mabhakitiriya yekurapa kwekuwedzera kwepulmonary kune vanhu vane cystic fibrosis.Miedzo yaisanganisirwa yakanga isina simba rakakwana rekuzadzisa zvinangwa zvavo.Nokudaro, hatikwanisi kuratidza kana kurapa kumwe kwaiva nani pane kumwe kana kuti kwete.Imwe tsvakiridzo inodiwa kuona kuti tobramycin yakafemerwa ingashandiswa here seimwe nzira kune intravenous tobramycin kune kumwe kuwedzera kwemapapu.