Products

Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) inonzi zinc-containing carboxypeptidase uye inodzivisa zvakanyanya fibrinolysis.TAFIa inhibitors inotarisirwa kuita se profibrinolytic agents.Isu munguva pfupi yapfuura takashuma dhizaini uye synthesis yeselenium-ine inhibitors yeTAFIa uye yavo inhibitory basa.Pano tinoshuma maitiro ekristaro eine simba selenium-, sulfur-, uye phosphinic acid-containing inhibitors inosungirirwa kune porcine pancreatic carboxypeptidase B (ppCPB).ppCPB ndeye TAFIa homologue uye inotsiva TAFIa yecrystallographic ongororo.Crystal zvimiro zveppCPB zvakasanganiswa neselenium compound 1a, sarufa analogue 2, uye phosphinic acid derivative EF6265 yakatemwa pa1.70, 2.15, uye 1.90 Å resolution, zvichiteerana.Imwe neimwe inhibitor inosunga kune inoshanda saiti yeppCPB nenzira yakafanana kune yakacherechedzwa kune yakambotaurwa inhibitors.Saka, mumacomplexes, selenium, sulfur, uye phosphinic acid okisijeni inobatanidza kune zinc muppCPB.Uku ndiko kutarisa kwekutanga uye chirevo cheselenium inobatanidza kune zinc muCPB.