Chloramphenicol CAS: 56-75-7 99% White powder
| Catalog Number | XD90355 |
| Product Name | Chloramphenicol |
| CAS | 56-75-7 |
| Molecular Formula | C11H12Cl2N2O5 |
| Molecular Weight | 323.13 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29414000 |
Chigadzirwa Specification
| Melting Point | 149.0°C - 153.0°C |
| pH | 4.5-7.5 |
| Assay | 99% |
| Chitarisiko | Upfu chena |
| Heavy metals | <20ppm |
| Kurasika paKuomesa | 0.5% max |
| Residue paIgnition | <0.10% |
Iyo brucellae ndiyo etiological agents yebrucellosis, zoonosis yakaparadzirwa pasi rose.Aya mabhakitiriya ari facultative intracellular parasites uye nekudaro anokwanisa kugadzirisa metabolism yavo kune yakawedzera- uye intracellular nharaunda inosangana panguva yehutachiona.Nekudaro, ichi chikamu cheBrucella biology hachina kunzwisiswa, uye chikafu chinowanikwa mune intracellular niche hazvizivikanwe.Pano, takaongorora nzira dzepakati dzeC metabolism inoshandiswa naBrucella abortus nekudzima putative fructose-1,6-bisphosphatase (fbp uye glpX), phosphoenolpyruvate carboxykinase (pckA), pyruvate phosphate dikinase (ppdK), uye malic enzyme (mae) majini.Mune gluconeogenic asi kwete muhupfumi hwehupfumi, kukura kweΔppdK uye Δmae mutants yakanga yakaremara zvikuru uye kukura kwekaviri Δfbp-ΔglpX mutant yakaderedzwa.Mune macrophages, chete ΔppdK uye Δmae mutants yakaratidza kuderedzwa kuwedzera, uye zvidzidzo ne ΔppdK mutant zvakasimbisa kuti yakasvika niche inodzokorora.Saizvozvowo, chete iyo ΔppdK uye Δmae mutants yakaderedzwa mumakonzo, iyo yekare ichicheneswa nevhiki 10 uye iyo yekupedzisira inoramba yakareba kupfuura mavhiki e12.Isu takaongorora zvakare glyoxylate cycle.Kunyangwe aceA (isocitrate lyase) yekusimudzira chiitiko yakakwidziridzwa mune yakapfuma svikiro, aceA kuvhiringika kwaisave nemhedzisiro mu vitro kana pakuwanza mu macrophages kana mbeva spleens.Zvigumisiro zvinoratidza kuti B. abortus inokura intracellularly ichishandisa zvishoma zve6-C (uye 5-C) shuga inobhadharwa ne glutamate uye zvichida mamwe amino acids anopinda muKrebs cycle pasina basa rinokosha re glyoxylate shunt.
