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Cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ikemikari yemakemikari inowana kushandiswa mumunda wemakemikari emishonga uye kukura kwezvinodhaka.Chimiro chayo chemolecular chinosanganisira pyrrolidine mhete ine tert-butyl boka panzvimbo yecis, boka re ethyl, uye mapoka maviri e-carboxylate.Mushonga uyu unowanzo wanikwa muchimiro chemunyu wehydrochloride.Chimwe chekushandiswa kukuru kwecis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride iri mukugadzirwa nekugadzirwa kwemishonga inonangana nechepakati. nervous system (CNS).Kuvapo kwemhete yepyrrolidine, pamwe chete nemapoka e-tert-butyl uye ethyl, inopa iyi komputa ine inogona kuita neuroactive properties.Vatsvaguri vanogona kushandisa iyi komputa sechinhu chekutanga kugadzira analog kana madhirivhari anogona kusarudza kupindirana nemamwe ma receptors kana enzymes muCNS.Nekugadzirisa maumbirwo uye zvinotsiva, vanogona kukwidziridza pharmacokinetic yekomboni, kuwedzera hukama hwayo hwekugamuchira, uye kuvandudza kugona kwayo kwekurapa. Uyezve, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride inogona kuva. inoshandiswa sechishandiso chemushonga muzvidzidzo zvebhayoloji kuti iongorore basa remareceptor chaiwo kana ma enzymes mumaitiro etsinga.Nekushandisa komisheni iyi se ligand kana probe, vaongorori vanogona kudzidza kusungirira hukama, kusarudza, uye maitiro ekuita kweaya mareceptor kana enzymes.Ruzivo urwu rwakakosha pakunzwisisa hwaro hwemamolecular ezve neuropharmacological process uye mukugadzirwa kwenovel therapeutics yakanangana neurodegenerative kusagadzikana, mamiriro epfungwa, kana chirwere chetsinga.Komboni iyi ine zvakare inogona kushandiswa mukutsvaga zvinodhaka uye yakakwirira-kuburikidza kuongorora assays.Inogona kuiswa mumaraibhurari emakomponi, ayo anoongororwa achipesana nezvinangwa zvakasiyana-siyana, senge ma receptors kana ma enzymes, kuona zvinogona kutungamirira makomisheni kana vanoda zvinodhaka.Kuongorora uku kunobvumira kuzivikanwa kwemakemikari anoratidza zvinhu zvinodikanwa zvemishonga kana zvinogona kurapa maitiro.Uyezve, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride inogona kuwana kushandiswa mukugadzirwa kweprodrugs.Maprodrugs haashande kana mashoma anoshanda makomisheni akagadzirwa kuti agadzirwe muchimiro chawo anoshanda kamwe mukati memuviri.Nekugadzirisa chimiro chekomboni iyi, vaongorori vanogona kugadzira mafomu eprodrug akanyanya kugadzikana, akavandudza bioavailability, kana anogona kuyambuka biological membranes zviri nyore.Izvi zvinogona kukwidziridza mabhenefiti emukomboni uye kuvandudza maitiro ayo emu pharmacokinetic.Muchidimbu, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride musanganiswa une zvinogona kushandiswa mukugadzirwa kweCNS-inotangwa zvinodhaka. , sechishandiso chemusanganiswa wezvidzidzo zvebhayoloji, mukuwanikwa kwezvinodhaka, uye mukugadzirwa kwezvigadzirwa.Yayo yakasarudzika molecular chimiro inopa mikana yekugadziridzwa uye optimization yekusimudzira yayo yemishonga zvimiro uye biological zviitiko.Iko kuita kwakasiyana-siyana uye kugona kwekomboni iyi kunoita kuti ive yakakosha mundima yemishonga chemistry uye kugadzirwa kwezvinodhaka.