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Cardioprotectant: Creatine phosphate chinhu chakakosha chekupa simba mumisumbu kuputika uye metabolism.Ndiyo kemikari simba rekuchengetedza yemhasuru yakatsetseka uye striated tsandanyama, uye inoshandiswa kune ATP resynthesis.Phosphocreatinedisodium ndiyo nzira yayo yekurapa.Sodium Creatine Phosphate, kemikari zita N-[imino(phosphono)methyl]-N-methylglycine disodium munyu, is cardioprotective agent yakatangwa neItaly Ouhui Pharmaceutical Factory muna 1992. Iyo phosphocreatine fomu inotamba zvakasiyana-siyana zvakakosha zvemuviri, uye inoshandiswa zvakanyanya. nokuda kwekuchengetedzwa kwemyocardial muvarwere vane cardiac ischemia kana panguva yemwoyo Chemicalbook kuvhiyiwa, uye nokuda kwekurapa kwezvirwere zvemwoyo zvakadai sekushaya mwoyo, myocardial infarction uye arrhythmia.Inogona kuvandudza kushanda kwemwoyo uye kuchinja kwemoyo kune varwere vane ischemic cardiomyopathy.Iyo haigone kupa simba remyocardial masero pavanenge vachitambura ne ischemia uye hypoxia, asiwo kudzivirira myocardial cell membranes kubva pakupinda kweokisijeni isina radicals uye zvimwe zvinhu zvinokuvadza, izvo zvinogona kukanganisa basa remwoyo.Kudzivirirwa kwemyocardial mushure mevarwere vane chirwere chisingakwanisi chevhavha chinobatsira kupora mushure mekugadzirisa basa remwoyo kune varwere vane chirwere chisingakwanisi chevhavha.Kuishandisa kurapa zvakakwana kukuvadzwa kwemyocardial mushure mekuzvarwa asphyxia kunogona kuvandudza zvakanyanya myocardial enzymes uye electrocardiogram, uye ine yakanaka yekurapa maitiro uye kuchengeteka.

Maitiro ekushanda Ichi chigadzirwa ikemikari simba rekuchengetedza yemoyo uye skeletal tsandanyama, uye inoshandiswa pakugadzirisazve ATP, ichipa simba rekuita kweiyo actomyosin contraction, uye inoita basa rakakosha musimba remetabolism yekuputika kwemhasuru.Kusakwana kwesimba rekupa chinhu chakakosha mukuumbwa uye kukura kwekukuvara kwemyocardial cell.

1. Iine simba guru rekudzivirira pane ischemic myocardial systolic function, iyo inogona kudzorera zvakakwana contractility uye nokukurumidza kuderedza diastolic blood pressure.

2. Chengetedza zvinyorwa zveadenosine triphosphate uye creatine phosphate mumasero, uye Chemicalbook inochengetedza myocardial energy reserve.

3. Deredza kurasikirwa kwe creatine kinase uye kuderedza kukanganisa kwesero membrane.

4. Iine anti-peroxidation properties.

5. Kuvandudza myocardial microcirculation.Nekuda kwekuvapo kwepamusoro-simba phosphate bond mu creatine phosphate mamorekuru, iyo yakakwirira-simba phosphate bond inogona kushandura zvakananga ADP kuita ATP pasi pechiito che creatine phosphate, uye yakananga kupa simba kumuviri kuti uite nekukurumidza.Sechigadzirwa chepakati cheglycolysis, sodium fructose diphosphate inoda kuita zvisina kunanga basa kuburikidza neanaerobic metabolism.

synthetic nzira:

1 Uchishandisa dibenzyl phosphate seyakabikwa, ita ne oxalyl chloride kuwana dibenzyl oxyphosphoryl chloride,

2 Pasi pechiito che triethylamine, dibenzyloxyphosphoryl creatine ethyl ester yakawanikwa nekuita ne creatine ethyl ester hydrochloride inofambiswa ku dibenzyloxyphosphoryl creatinine,

3. Mushure mepalladium carbon catalyzed hydrogenolysis to debenzylate, react with sodium hydroxide kuwana disodium creatinine phosphate,

4 ine hydrolyzed kune 1 pasi pekuita kwe sodium hydroxide.

Zvishandiso: Yakakodzera kuchengetedza iyo isina kujairika myocardial metabolism mumyocardial ischemia.

Kuita kwakashata, kupikisa uye zvinodhaka zvinodhaka: avo vane allergic kune zvikamu zvechigadzirwa ichi zvinorambidzwa;avo vane chisingaperi renal insufficiency vanorambidzwa kushandisa mishonga yakakura (5-10g / d).Rapid intravenous jekiseni rinopfuura 1g rinogona kukonzera kudzikira kweBP.High-dose administration inoguma nepamusoro phosphate kudya, iyo inogona kukanganisa calcium metabolism uye secretion yehomoni inodzora homeostasis, inokanganisa renal basa uye purine metabolism.