Cytidine-5'-triphosphate (CTP), disodium munyu CAS:652154-13-7
| Catalog Number | XD90551 |
| Product Name | Cytidine-5'-triphosphate (CTP), disodium munyu |
| CAS | 652154-13-7 |
| Molecular Formula | C9H14N3Na2O14P3 |
| Molecular Weight | 527.12 |
| Storage Details | 2 kusvika ku8 °C |
Chigadzirwa Specification
| Chitarisiko | Upfu chena |
| Assay | 99% |
CTP:phosphocholine cytidylyltransferase α (CCTα) ienzyme yenyukireya inokonzera nhanho-yekumisa nhanho muCDP-choline nzira ye phosphatidylcholine (PC) synthesis.Lipid activation yeCCTα inoguma nekuendeswa kune envelopu yenyukireya uye kuwedzera kweiyo intranuclear membrane network inodaidzwa kuti nucleoplasmic reticulum (NR) nemuchina unosanganisira membrane deformation.Nuclear maramu anodiwawo pakudzikama uye kuwanda kweNR, asi kuti iyi yakasarudzika chimiro, kana nyukireya lamina kazhinji, inodiwa paPC synthesis hazvizivikanwe.Kuti uongorore hukama uhwu, lamina yenyukireya yakaderedzwa neRNAi kana kuvhiringidzwa nekutaura kweHutchinson-Gilford progeria syndrome (HGPS) mutant lamin A (progerin), uye mhedzisiro yeCCTα uye choline metabolism yakaongororwa.siRNA-mediated kunyarara kwelamin A/C kana lamin B1 mumaseru eCHO kuderedza NR kwaisava nemhedzisiro paPC synthesis, uku kugogodza kaviri kusiri-kunyatso kuvharira nzira.Kusimbisa t basa rake diki muPC synthesis, chete 10% yenguva pfupi yakawandisa yakawedzera choline/ethanolamine phosphotransferase yakaonekwa muNR.MuC CHO masero, CCTα yaiva nucleoplasmic uye co-localized neGFP-progerin mumakumbo enyukireya uye invaginations;zvisinei, HGPS fibroblasts yakaratidza kuparadzirwa kusina kujairika kweCCTα mu cytoplasm uye envelopu yenyukireya iyo yaiperekedzwa ne 2-kupeta kuderedzwa kwePC synthesis.Pasinei nekushandurwa kwayo kwenzvimbo, kuongorora kwe-choline-labeling kwakaratidza kuti chiitiko cheCCT chakanga chisina kukanganiswa, uye kudziviswa kwePC synthesis kwakateverwa kune kuderedzwa kwekuita kwehemicholinium-sensitive choline transporter.Isu tinogumisa kuti CCTα nemalami anonyatso kubatirana kuumba iyo NR, asi iyo yakazara dhizaini yehamvuropu yenyukireya ine mhedzisiro shoma paCCT chiitiko uye PC synthesis.
