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D-Mannitol Cas: 69-65-8 96-101.5% White crystalline poda

Tsanangudzo Pfupi

Catalog Number: XD90226
Cas: 69-65-8
Molecular Formula: C6H14O6
Molecular Weight: 182.1718
Kuwanikwa Mudura
Mutengo:  
Prepack: 1kg USD10
Bulk Pack: Kumbira Quote

 

 

 

 

 

 


Product Detail

Product Tags

Catalog Number XD90226
Product Name D-Mannitol

CAS

69-65-8

Molecular Formula

C6H14O6

Molecular Weight

182.1718
Storage Details Ambient

Harmonised Tariff Code

29054300

 

Chigadzirwa Specification

Melting Point 164 - 169 Deg C
Giredhi BP
Kutenderera chaiko +23 - +25
AS <1ppm
Kurasika paKuomesa <0.3%
Sulfate <0.01%
Assay 96 - 101.5%
Nickel ≤ 1ppm
Acid <0.2ml
Kuderedza Shuga ≤ 0.1%
Conductivity ⩽ 20us/cm
Cl <0.007%
Chitarisiko White crystalline powder

 

Kuti tiongorore basa reoxidative stress uye/kana mitochondrial impairment pakuitika kwekukuvadzwa kweitsvo kwakanyanya (AKI) panguva yesepsis, takagadzira sepsis-induced in vitro model tichishandisa proximal tubular epithelial cells akazarurwa kune bacterial endotoxin (lipopolysaccharide, LPS).Tsvagiridzo iyi yakapa maficha akakosha pahukama pakati peoxidative kusagadzikana uye mitochondrial yekufema cheni chiitiko chirema.Kurapa kweLPS kwakakonzera kuwedzera kwekutaura kweinducible nitric oxide synthase (iNOS) uye NADPH oxidase 4 (NOX-4), zvichiratidza cytosolic overexpression yenitric oxide uye superoxide anion, iyo yekutanga reactive nitrogen marudzi (RNS) uye reactive okisijeni marudzi. (ROS).Iyi oxidant state yaiita seyakanganisira mitochondrial oxidative phosphorylation nekudzikisa cytochrome c oxidase chiitiko.Nekuda kweizvozvo, kukanganisika mukufambisa kwemaerekitironi uye kupomba kweproton nepakati pemitochondrial membrane yemukati kwakaitika, izvo zvakakonzera kudzikira kweiyo mitochond rial membrane inogona, kuburitswa kweapoptotic-inducing factor uye kuderera kweadenosine triphosphate.Sezvineiwo, mushure mekunangwa neRNS neROS, mitochondria yakazove mugadziri weROS, nokudaro zvichibatsira kuwedzera mitochondrial dysfunction.Basa re oxidants mumitochondrial dysfunction rakasimbiswa zvakare nekushandiswa kweNOS inhibitors kana antioxidants inochengetedza cytochrome c oxidase basa uye kudzivirira mitochondrial membrane inogona kuparara.Mhedzisiro iyi inoratidza kuti sepsis-induced AKI haifanirwe kungoonekwa sekutadza kwesimba resimba asiwo semhinduro yakabatanidzwa, kusanganisira zviitiko zvekunyorwa, ROS kusaina, mitochondrial chiitiko uye metabolic orientation senge apoptosis.


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    D-Mannitol Cas: 69-65-8 96-101.5% White crystalline poda