D-Mannitol Cas: 69-65-8 96-101.5% White crystalline poda
| Catalog Number | XD90226 |
| Product Name | D-Mannitol |
| CAS | 69-65-8 |
| Molecular Formula | C6H14O6 |
| Molecular Weight | 182.1718 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29054300 |
Chigadzirwa Specification
| Melting Point | 164 - 169 Deg C |
| Giredhi | BP |
| Kutenderera chaiko | +23 - +25 |
| AS | <1ppm |
| Kurasika paKuomesa | <0.3% |
| Sulfate | <0.01% |
| Assay | 96 - 101.5% |
| Nickel | ≤ 1ppm |
| Acid | <0.2ml |
| Kuderedza Shuga | ≤ 0.1% |
| Conductivity | ⩽ 20us/cm |
| Cl | <0.007% |
| Chitarisiko | White crystalline powder |
Kuti tiongorore basa reoxidative stress uye/kana mitochondrial impairment pakuitika kwekukuvadzwa kweitsvo kwakanyanya (AKI) panguva yesepsis, takagadzira sepsis-induced in vitro model tichishandisa proximal tubular epithelial cells akazarurwa kune bacterial endotoxin (lipopolysaccharide, LPS).Tsvagiridzo iyi yakapa maficha akakosha pahukama pakati peoxidative kusagadzikana uye mitochondrial yekufema cheni chiitiko chirema.Kurapa kweLPS kwakakonzera kuwedzera kwekutaura kweinducible nitric oxide synthase (iNOS) uye NADPH oxidase 4 (NOX-4), zvichiratidza cytosolic overexpression yenitric oxide uye superoxide anion, iyo yekutanga reactive nitrogen marudzi (RNS) uye reactive okisijeni marudzi. (ROS).Iyi oxidant state yaiita seyakanganisira mitochondrial oxidative phosphorylation nekudzikisa cytochrome c oxidase chiitiko.Nekuda kweizvozvo, kukanganisika mukufambisa kwemaerekitironi uye kupomba kweproton nepakati pemitochondrial membrane yemukati kwakaitika, izvo zvakakonzera kudzikira kweiyo mitochond rial membrane inogona, kuburitswa kweapoptotic-inducing factor uye kuderera kweadenosine triphosphate.Sezvineiwo, mushure mekunangwa neRNS neROS, mitochondria yakazove mugadziri weROS, nokudaro zvichibatsira kuwedzera mitochondrial dysfunction.Basa re oxidants mumitochondrial dysfunction rakasimbiswa zvakare nekushandiswa kweNOS inhibitors kana antioxidants inochengetedza cytochrome c oxidase basa uye kudzivirira mitochondrial membrane inogona kuparara.Mhedzisiro iyi inoratidza kuti sepsis-induced AKI haifanirwe kungoonekwa sekutadza kwesimba resimba asiwo semhinduro yakabatanidzwa, kusanganisira zviitiko zvekunyorwa, ROS kusaina, mitochondrial chiitiko uye metabolic orientation senge apoptosis.
