D-Valine Cas: 640-68-6 C5H11NO2
| Catalog Number | XD90291 |
| Product Name | D-Valine |
| CAS | 640-68-6 |
| Molecular Formula | C5H11NO2 |
| Molecular Weight | 117.14634 |
| Storage Details | Room Temp |
| Harmonised Tariff Code | 29224995 |
Chigadzirwa Specification
| Assay | 99% |
| Chitarisiko | Upfu chena |
| Density | 1.2000 (kufungidzira) |
| Melting point | >295 °C (subl.) (lit.) |
| Boiling point | 213.6 °C pa760 mmHg |
| Flash point | 83℃ |
| Refractive index | -27 ° (C=8, 6mol/L HCl) |
| Solubility | 56 g/L (20°C) |
| Kunyungudika kwemvura | 56 g/L (20 ºC) |
| PSA | 63.32000 |
| LogP | 0.75460 |
| Kutenderera chaiko | -27.5 º (c=5, 5N HCl) |
| Optical chiitiko | [α]23/D −32.0 kusvika −24.0°, c = 8 mu6 M HCl |
Vakadzi vane antiphospholipid syndrome (APS) vari panjodzi yakawedzera yekurasikirwa nemimba zvakare (RPL) uye preeclampsia.Antiphospholipid antibodies (aPL) inoshandura zvakananga trophoblast basa.Kurapa nelow molecular weight heparin (LMWH) kunoderedza njodzi yeRPL asi kwete preeclampsia.Uyezve, LMWH inokurudzira trophoblast sFlt-1 kusunungurwa, anti-angiogenic factor inobatanidza ne preeclampsia.Sezvo kushaikwa kwevhitamini D kwakabatana neAPS uye preeclampsia, chidzidzo ichi chakatsvaga kuona mhedzisiro yevhitamini D pane trophoblast basa mukugadzika kweaPL uye LMWH.A human first trimester trophoblast cell line (HTR8) uye primary trophoblast tsika dzakarapwa kana pasina aPL mukuvapo uye kusavapo kwevhitamini D, LMWH kana zvese zviri zviviri.Trophoblast secretion of inflammatory cytokines uye angiogenic factors zvakayerwa neELISA.Vitamin D chete kana kusanganiswa neLMWH yakaderedza aPL-induced trophoblast inflammatory response mumasero eHTR8 uye tsika dzekutanga.Kunyange zvazvo vhitamini D yakanga isina kukanganisa paPL-mediated modulation yeangiogenic factor in the primary trophoblast, yakanyanya kuvharidzira LMWH-induced sFlt-1 kusunungurwa.LMWH pamwe chete nevhitamini D inogona kubatsira kudarika single-agent therapy nekudzivirira aPL. -induced trophoblast kuzvimba uye kudzorera LMWH-induced sFlt-1 secretion.
