DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) CAS:28718-90-3 99% Yellow powder
| Catalog Number | XD90505 |
| Product Name | DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) |
| CAS | 28718-90-3 |
| Molecular Formula | C16H15N5 · 2HCl |
| Molecular Weight | 350.25 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 2933998090 |
Chigadzirwa Specification
| Chitarisiko | Yellow powder |
| Assay | 99% min |
| Zvekutsvaga kushandiswa chete, kwete zvekushandisa kwevanhu | Tsvagiridzo inoshandiswa chete, kwete yekushandiswa kwevanhu |
Melatonin inobatanidzwa mumabasa akawanda emuviri, uye ine mutsauko mhedzisiro pane apoptosis mune akajairwa uye cancer maseru.Nekudaro, maitiro eayo antitumor mabasa haanyatso kunzwisiswa.Muchidzidzo ichi, tinoratidza kuti melatonin inowedzera tunicamycin-induced apoptosis mumazamu emunhu carcinoma MDA-MB-231 masero.Melatonin inokwira-inogadzirisa pro-apoptotic protein Bim kutaura pamatanho ekunyorwa pamberi petunicamycin.Melatonin inhibits tunicamycin-induced COX-2 kutaura muMDA-MB-231 masero.Uyezve, kudziviswa kweCOX-2 basa uchishandisa COX-2 inhibitor, NS398, inowedzera tunicamycin-induced apoptosis.Sezvineiwo, izvi mhedzisiro hazvina kubatanidzwa ne melatonin receptor chiratidzo nzira.Pertussis toxin (yakawanda Gi protein inhibitor) kana luzindole (asingatarisirwi melatonin receptor antagonist) haina kudzosera mhedzisiro yemelatonin.Mukuwedzera, melatonin yakavhara tunicamycin-induced NF-κB transcriptional basa, p65 nuclear translocation, uye p38 MAPK act ivation.Melatonin-mediated p38 MAPK inhibition yakabatsira mukudzikira COX-2 mRNA kugadzikana.Takatorwa pamwechete, mhedzisiro yedu inoratidza kuti melatonin inosimudzira antitumor basa kuburikidza ne-up-regulation yeBim kutaura uye pasi-mutemo we COX-2 kutaura mu tunicamycin-inorapwa MDA-MB-231 masero.
