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Iyo N7/O6 equatorial inosunga kudyidzana kweiyo antitumor inoshanda yakaoma Rh(2)(OAc)(4)(H(2)O)(2) (OAc(-) = CH(3)CO(2)(-)) neDNA fragment d(GpG) yakatemwa zvisina kujeka neNMR spectroscopy.Yakapfuura X-ray crystallographic determinations yemusoro-kune-musoro (HH) uye musoro-to-muswe (HT) adducts ye dirhodium tetraacetate ine 9-ethylguanine (9-EtGH) yakaratidza kusati kwamboitika bhiriji N7/O6 guanine nucleobases inotenderera Rh. -Rh chisungo.Kusavapo kweN7 protonation pane yakaderera pH uye kuwedzera kunoshamisa kwe acidity yeN1-H (pK (a) inenge 5.7 kana ichienzaniswa ne8.5 yeN7 chete yakasungwa platinum adducts), inokurudzirwa ne pH kutsamira titrations ye purine H8 (1 )H NMR resonances yeRh(2)(OAc)(2)(9-EtG)(2) uye Rh(2)(OAc)(2-)[d(GpG)],inofambirana ne bidentate N7/O6 inosunga yeGuanine nucleobases.Iyo pK(a) tsika dzinofungidzirwa kuti N1-H (de) protonation, kubva kupH kutsamira zvidzidzo zveC6 neC2 (13)C NMR resonances yeRh(2)(OAc)(2)(9-EtG)( 2) isomers, inopindirana net hose yakatorwa kubva kuH8 (1) H NMR resonance titrations.Kuenzanisa kwe (13) C NMR resonances yeC6 uye C2 ye dirhodium adducts Rh (2) (OAc) (2) (9-EtG) (2) uye Rh (2) (OAc) (2) [d (GpG) )] ine resonances inoenderana neiyo isina kusungwa ligands [pa pH 7.0 ye9-EtGH uye pH 8.0 ye d(GpG)], inoratidza yakakura kudzika kwepasi kuchinjika kweDeltadelta ingangoita 11.0 uye 6.0 ppm yeC6 neC2, zvichiteerana;iwo ekupedzisira anochinja anoratidza mhedzisiro yeO6 inosunga kune dirhodium nzvimbo uye kunotevera kuwedzera mu acidity yeN1-H.Yakanyanya H8/H8 ROE inoyambuka-pamusoro-soro mu2D ROESY NMR spectrum yeRh(2)(OAc)(2)[d(GpG)] inoratidza kurongeka kwemusoro-kune-musoro kwezvigadziko zveguanine.The Rh(2)(OAc)(2)[d(GpG)] adduct inoratidza maviri makuru ekurudyi anofananidzira, HH1 R neHH2 R, neHH1 R ichiwanda zvakapetwa katatu pane zvisina kujairika HH2 R. maadducts anoratidza kuramba kwe5'-G shuga mhete kuC3'-endo (N-rudzi), kuchengetwa kweC2'-endo (S-type) conformation ye3'-G sugar rin gs, uye anti orientation maererano ne iyo glycosyl zvisungo.Zvimiro zvakawanikwa zveRh(2)(OAc)(2))[d(GpG)] nenzira yeNMR spectroscopy zvakafanana zvikuru neaya ecis-[Pt(NH(3)))(2))[d( GpG)]] uye inotsigira zvidzidzo zvemamolecular modelling.