Doxorubicin hydrochloride CAS: 25316-40-9 99% Orange-tsvuku Crystalline poda
| Catalog Number | XD90367 |
| Product Name | Doxorubicin hydrochloride |
| CAS | 25316-40-9 |
| Molecular Formula | C27H29NO11·HCl |
| Molecular Weight | 579.98 |
| Storage Details | 2 kusvika ku8 °C |
| Harmonised Tariff Code | 29419000 |
Chigadzirwa Specification
| MvuraContent | ≤ 4.0% |
| pH | 4.0-5.5 |
| Solubility | Soluble mu: mvura, methanol uye isotonic NaCl (aq).Kusakwana kunyungudika muchloroform uye mamwe organic solvents. |
| Related Substances | Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Assay | 99% |
| Residual Solvents | Acetone uye doro: ≤2.5% / Acetone: ≤0.5% / Methanol: ≤500ppm |
| Chero Zvimwe Zvisina Kuchena | ≤ 0.5% |
| Zvose Zvisina Kuchena | ≤ 2.0% |
| Crystallinity | Inoenderana neUSP |
| Chitarisiko | Orange-tsvuku Crystalline poda |
| Identification | HPLC |
Varwere vane P-glycoprotein uye HER2/neu (HER2) receptor-overexpressing cancer yemazamu kazhinji vane mhedzisiro yekiriniki yakaipa.Zvisineyi, hapana mitsara yekenza yemazamu inotengeswa iri HER2/P-glycoprotein yakapetwa kaviri, iyo inoganhurira tsvakiridzo munharaunda iyi. cancer cell line nekuchinjika kwakadzikama kweATP-binding cassette (ABC) subfamily B member 1 (ABCB1) gene iyo encodes P-glycoprotein.ABCB1 gene expression mazinga aive akakwira mushure mekutapurirana, izvo zvakaita kuti kuwedzera makumi mana muP-glycoprotein. kutaura.Sezvineiwo, kutapurirana kweABCB1 kwakakonzerawo kuwedzera kudiki kweHER2 gene uye mapuroteni ekutaura mazinga.Kutapurirwa kweABCB1 kwakawedzera mazinga ekutaura kweP-glycoprotein zvakanyanya.Nzira inoshandiswa pano pakugadzira iyi mutsara wesero inokodzera kukurumidza, yakagadzikana induction yeP-glycoprotein-mediated drug resistance kana ichienzaniswa netr aditional nzira.Iyo in vitro cytotoxicity bvunzo inoratidza iyi sero mutsara ine muchinjiko-kupikisa kune dzakasiyana siyana dze chemotherapeutic agents.
