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Mhedzisiro ye acidosis, chiratidzo chebiochemical che tumor microenvironment, pakukura kwegomarara uye metastasis yakaoma.Zvese zviri zviviri pro- uye anti-tumorigenic mhedzisiro ye acidosis yakashumwa uye iyo acidic microenvironment yakashandiswa kune chaiyo kuendesa zvinodhaka, maejenti ekufungidzira, uye majini anovaka mumamota.Muchidzidzo ichi tinoongorora kupararira nekunamira kwakasimba kweB16F10 melanoma masero akagadzirwa nemajini kuti awedzere kuwedzeredza pH-sensing G protein-coupled receptor GPR4.Nekushandisa maseru ekunamirwa assays takaona kuti GPR4 overexpression yakanonoka kupararira kwesero uye yakashandura nzvimbo yenzvimbo ye dynamic focal adhesion complex, sekugariswa kwephosphorylated focal adhesion kinase (FAK) uye paxillin, ine acidic pH.Iyo inogona kuitika yeG-protein uye yakadzika masaini nzira nzira dzinokonzeresa izvi zvakaongororwa zvakare.Nekushandisa Rho inhibitor CT04 (C3 transferase), Rho-associated kinase (ROCK) inhibitors Y27632 uye thiazovivin, iyo myosin light chain kinase (MLCK) inhibitor staurosporine kana G12/13 inhibitory construct, kupararira kwesero kwakadzorerwa uye inhibitor activation yeGq neGs nzira kwaive nekushomeka kana kusave nemhedzisiro.Zvose zvatakawana zvinoratidza kuti kuburikidza neG12 / 13 / Rho nzira yekucherechedza GPR4 inogadzirisa focal adhesion dynamics uye inoderedza kupararira kwesero uye membrane ruffling.