Folic Acid Cas: 59-30-3 99%
| Catalog Number | XD90435 |
| Product Name | Folic Acid |
| CAS | 59-30-3 |
| Molecular Formula | C19H19N7O6 |
| Molecular Weight | 441.40 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29362900 |
Chigadzirwa Specification
| Chitarisiko | Yero kana orenji crystalline upfu |
| Assay | 99% |
| Mvura | 5.0 - 8.5% |
| Chromatographic kuchena | <2.0% |
| Solubility | Inenge isinganyungudika mumvura uye yakawanda organic solvents.Inonyungudika mu dilute acids uye mune alkaline mhinduro |
| Residue paIgnition | <0.3% |
Muchidzidzo ichi, thermosensitive uye folate functionalized poly(ethylene oxide) -b-poly(propylene oxide)-b-poly(ethylene oxide) -ploy(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) copolymer yaiva synthesized.Chimiro uye uremu hwemamorekuru ecopolymer zvakasimbiswa ne1H NMR, FT-IR uye GPC, zvichiteerana.Iyo yakaderera yakakosha yekugadzirisa tembiricha (LCST) yecopolymer yaive 39.8 madhigirii C. Nekushandisa doxorubicin (DOX) semushonga wemuenzaniso, folate receptor-targeted DOX-yakatakura micelles yakawedzera kuumbwa pane copolymer.Iwo asina chinhu uye DOX-akatakura micelles ese airatidza anenge akatenderera zvimiro uye avhareji madhayamita aive 35 nm uye 50 nm, zvichiteerana.Iyo in vitro kuburitsa maitiro eiyo DOX-yakarodha micelles yaive tembiricha-inotsamira uye mwero wekuburitswa kweDOX pa42 degrees C (pamusoro peLCST) yakakurumidza kupfuura iyo pa37 degrees C (pazasi peLCST).Uyezve, iyo cytotoxicity assays yemahara DOX uye DOX-yakatakura micelles pamunhu cervical cancer cell mitsara HeLa uye yemapapu emapapu emunhu cell mitsara A549 yakaratidza kuti folate yakawedzera cellular kutora kwema micells mukati memasero akatarwa ayo akanyanya-kuratidzwa folate receptors.
