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Bromelain (BR) inonzi cysteine ​​​​protease ine inhibitory mhedzisiro pakuvanzika kwematumbo uye kuzvimba.Nekudaro, mhedzisiro yayo paintestinal motility haina kunyanya kuongororwa.Saka, takaongorora mhedzisiro yeiyi chirimwa-yakabva mukomboni pane intestinal contractility uye kufamba mumakonzo.Contractility in vitro yakaongororwa nekukurudzira mbeva yakasarudzika ileum, muorgan bath, ine acetylcholine, barium chloride, kana magetsi emunda stimulation.Motility in vivo yakayerwa nekuongorora kugoverwa kwechiratidzo chefluorescent chinoitwa nemuromo padumbu mudiki.Kufambisa kwakaongororwawo mune pathophysiologic states inokonzerwa nepro-inflammatory compound croton oil kana ne diabetogenic agent streptozotocin.Bromelain inhibited contractions inokonzerwa nemhando dzakasiyana-siyana dze spasmogenic muleum ye mouse ine simba rakafanana.Iyo antispasmodic effect yakaderedzwa kana kupikisa neproteolytic enzyme inhibitor, gabexate (15 × 10 (-6) mol L (-1)), protease-activated r eceptor-2 (PAR-2) anopikisa, N (1) -3 -methylbutyryl-N(4) -6-aminohexanoyl-piperazine (10(-4) mol L(-1)), phospholipase C (PLC) inhibitor, neomycin (3 × 10(-3) mol L(-1)) , uye phosphodiesterase 4 (PDE4) inhibitor, rolipram (10(-6) mol L(-1)).In vivo, BR inosarudza inhibited motility mune pathophysiologic states nenzira yePAR-2-antagonist-sensitive.Dzimwe yedu inoratidza kuti BR inhibits intestinal motility - kunyanya mumamiriro epathophysiologic - ine nzira inogona kusanganisira membrane PAR-2 ​​uye PLC uye PDE4 se intracellular. zviratidzo.Bromelain inogona kuve inotungamira yekugadzira mishonga mitsva, inokwanisa kugadzirisa intestinal motility mukuzvimba uye chirwere cheshuga.