GSH Cas: 70-18-8 98% White crystalline powder
| Catalog Number | XD90227 |
| Product Name | GSH |
| CAS | 70-18-8 |
| Molecular Formula | C10H17N3O6S |
| Molecular Weight | 307.323 |
| Storage Details | 2 kusvika ku8 °C |
| Harmonised Tariff Code | 29309098 |
Chigadzirwa Specification
| Chigadzirwa Specification | |
| Melting Point | 185°C |
| Giredhi | Pharma Grade |
| Heavy metals | 10ppm max |
| Arsenic | 2ppm max |
| Identification | IR : Zvakafanana neReference Spectrum |
| Kurasika paKuomesa | 0.5% max |
| Storage Temperature | +20 ° C |
| Molecular Weight | 612.63 |
| Assay | 98.0% min |
| Optical Rotation | -15.5°- -17.5 deg |
| Residue paIgnition | 0.1% max |
| Kujeka Kwemhinduro | Zvakajeka uye zvisina ruvara |
| Chitarisiko | White crystalline powder |
| Related Substance | Zvose: 2.0% max, GSSG:1.5% max |
Iyo ORF45 protein yeKaposi's sarcoma-associated herpesvirus (KSHV) igammaherpesvirus-specific immediate-early tegument protein.Zvidzidzo zvedu zvakapfuura zvakaratidza basa rayo rakakosha mune ese ekutanga uye ekupedzisira matanho ehutachiona hweKSHV.Muchidzidzo ichi, takaongorora interactome yeORF45 tichishandisa boka remamonoclonal antibodies.Kuwedzera kune yakambozivikanwa extracellular regulated kinase (ERK) uye p90 ribosomal S6 kinase (RSK) mapuroteni, takawana akati wandei mapuroteni akaomeswa, anosanganisira akakurumbira e ~ 38 kDa uye ~ 130 kDa.Mass spectrometry yakaratidza kuti 38-kDa protein ine hutachiona ORF33 uye 130-kDa protein ndeye cellular USP7 (ubiquitin-specific protease 7).Takaronga iyo ORF33-binding domain kune yakanyanya kuchengetedzwa carboxyl-terminal 19 amino acids (aa) yeORF45 uye USP7-inosunga domain kune yakashumwa kubvumirana motif munharaunda yepakati yeORF45.Tichishandisa immunofluorescence staining, takaona colocalization yeORF45 ine ORF33 kana USP7 zvese zviri pasi pekutapukirwa condit ions uye mumaseru ane hutachiona hweKSHV.Uyezve, takaona ORF45-inotsamira kuchinjika kwechikamu cheORF33/USP7 kubva kunucleus kuenda kucytoplasm.Takaona kuti ORF45 yakakonzera kuwedzera kweORF33 protein accumulation iyo yakabviswa kana iyo ORF33- kana USP7-binding domain muORF45 yakabviswa.Uyezve, kubviswa kweiyo yakachengetedzwa carboxyl terminus yeORF45 muKSHV genome yakaderedza zvakanyanya mwero weORF33 protein mumaseru ane hutachiona hweKSHV uye kwakabvisa kugadzirwa kwevana virions.Pamwe chete, mhinduro dzedu hadzingobudisi pachena zvikamu zvitsva zveORF45 interactome, asi dzinoratidzawo kuti kusangana kwemapuroteni aya kwakakosha paKSHV lytic replication.Kaposi's sarcoma-associated herpesvirus (KSHV) ndiyo inokonzera gomarara revanhu rakati wandei.KSHV ORF45 ipuroteni inoshanda yakawanda inodiwa pakudzokorora kweKSHV lytic, asi nzira chaidzo dzinoitwa nadzo ORF45 dzinoita mabasa ayo akakosha hadzina kujeka.Zvidzidzo zvedu zvakapfuura zvakaratidza kuti ese ORF45 pr otein mumaseru aripo mune akakwira-mamorekuru-huremu complexes.Saka isu takatsvaga kuratidza iyo interactome yeORF45 kuti ipe nzwisiso mumabasa ayo panguva yelytic replication.Tichishandisa boka remamonoclonal antibodies, takaongorora iyo ORF45 interactome mumaseru ane hutachiona hweKSHV.Takaona vaviri vatsva vanosunga shamwari dzeORF45: the viral protein ORF33 uye cellular ubiquitin-specific protease 7 (USP7).Isu tinoenderera mberi tichiratidza kuti kudyidzana pakati peORF45 neORF33 kwakakosha pakugadzirwa kwakanaka kweKSHV viral particles, zvichiratidza kuti kupindira kwakanangwa nekudyidzana uku kunogona kumiririra nzira nyowani yekudzivisa KSHV lytic replication.
