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Idiopathic pulmonary fibrosis inofungidzirwa kuti inosanganisira kukuvara kwemapapu kunokonzerwa neiyo reactive oxygen marudzi (ROS), iyo inoteverwa neabnormal fibrosis.A shanduko yekukura chinhu (TGF) -β1-induced kuwedzera mumyofibroblast nhamba inoita basa rakakosha mune iyi isina kujairika fibrosis.Isu munguva pfupi yapfuura takaona kuti mepenzolate bromide (mepenzolate), iyo yakashandiswa kukiriniki kurapa gastrointestinal kusagadzikana, ine ROS-inoderedza zvinhu.Muchidzidzo chazvino, takaongorora maitiro emepenzolate pableomycin-induced pulmonary fibrosis uye kusashanda kwemapapu mumakonzo.Kuoma kwepulmonary fibrosis kwakaongororwa ne histopathological evaluation uye kutsunga kwemazinga ehydroxyproline.Lung mechanics (elastance) uye basa rekufema [kumanikidzwa kwakakosha simba (FVC)] zvakaongororwa pachishandiswa mhepo inodzorwa nekombuta.Basa rekufema rakaongororwawo nekutarisa percutaneous arterial oxygen saturation (SpO2).Intracheal administration ye mepenzolate isati yaitwa bleomycin kurapwa yakaderedza kuwanda kwepulmonary fibrosis uye shanduko mumapapu mechanics uye zvakakonzera kupora kukuru kwezvose FVC neSpO2 zvichienzaniswa nekutonga.Uyezve, mepenzolate yakagadzira kurapa kunyangwe payakaitwa mushure mekuvandudzwa kwefibrosis.Kutungamirirwa kwemepenzolate kwakadzivirirawo bleomycin-induced pulmonary cell death uye mhinduro dzekuzvimba uye kuwedzera myofibroblast nhamba.Mepenzolate yakaderedzawo basa reNADPH oxidase uye rinoshanda TGF-β1 level kana kuwedzera glutathione S-transferase (GST) basa pamberi pekurapa kwebleomycin.Izvi zvinoratidza kuti intracheal administration ye mepenzolate yakaderedza bleomycin-induced pulmonary fibrosis uye kusashanda kwemapapu mumakonzo.Mhedzisiro iyi inogona kunge iri nekuda kweiyo mushonga inhibitory effect paNADPH oxidase uye TGF-β1 zviitiko uye stimulatory effect paGST.