L-Tryptophan Cas: 73-22-3 99% White powder
| Catalog Number | XD90295 |
| Product Name | L-Tryptophan |
| CAS | 73-22-3 |
| Molecular Formula | C11H12N2O2 |
| Molecular Weight | 204.22518 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29339980 |
Chigadzirwa Specification
| Assay | 99% min |
| Chitarisiko | Upfu chena |
| Giredhi | USP32 |
| Kutenderera chaiko | -29.4 kusvika -32.8 |
| pH | 5.5 kusvika 7.0 |
| Fe | <0.003% |
| Pb | <0.0015% |
| Kurasika paKuomesa | <0.3% |
| Residue paIgnition | 0.1%max |
| Cl | 0.05%max |
Indoleamine 2,3-dioxygenase (IDO1) uye tryptophan 2,3-dioxygenase (TDO) ma enzymes maviri akasiyana ane maitiro akasiyana-siyana ane kuparadzirwa kwetishu uye mabasa ehupenyu, asi zvose zvinokonzera kutendeuka kwe tryptophan kuN-formylkynurenine (NFK).IDO1 yakasimbiswa nekiriniki sediki-morekuru mushonga wakanangana negomarara, nepo preclinical zvidzidzo zvinoratidza kuti TDO inogona kunge iri chinangwa chegomarara immunotherapy uye neurodegenerative chirwere.Isu takagadzira yakakwira-kuburikidza yekuongorora assay yeIDO1 uye TDO yakavakirwa pane inoveli kemikari probe, NFK Green, inobata zvakananga neNFK kuumba green fluorescent molecule ine excitation wavelength ye400 nm uye emission wavelength ye510 nm.Isu tinopa yekutanga padivi-ne-padivi kuenzanisa yeakawanda akadhindwa inhibitors eIDO1 neTDO uye tinoratidza kuti preclinical IDO1 inhibitor Compound 5l inoratidza yakakosha kuyambuka-reactivity neTDO, ukuwo kusarudzwa kwemamwe akadhindwa inhibitors kwakasimbiswa.Iyo suitabil ity yekuongororwa kwepamusoro-soro yeassays yakaratidzwa nekuongorora raibhurari ye87,000 kemikari zvinhu mu384- kana 1536-tsime fomati.Chekupedzisira, isu tinoratidza kuti muyedzo unogona zvakare kushandiswa kuyera kugona kweseru kuita metabolize tryptophan uye kuyera cellular potency yeIDO1 uye TDO inhibitors.
