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Linagliptin Yepakati F, inozivikanwawo se3-aminopiperidine-1-carboxylic acid, yakakosha kemikari musanganiswa we linagliptin, mushonga unoshandiswa kurapa chirwere cheshuga mellitus.Linagliptin ndeyeboka remishonga inozivikanwa se dipeptidyl peptidase-4 (DPP-4) inhibitors, iyo inobatsira kudzora mazinga eshuga. Linagliptin Yepakati F inoita basa rakakosha mumatanho ekupedzisira ekuumbwa kwelinagliptin.Inoshanda sechinhu chakakosha chekuvaka kugadzira iyo yakasarudzika makemikari chimiro che linagliptin nekuita zvakatevedzana maitiro.Ichi chepakati chinonyatso shandiswa mukugadzirwa kwepiperidine mhete yelinagliptin's molecular structure.Kana yangogadzirwa, linagliptin inoshanda nekuvharisa enzymatic chiitiko cheDPP-4.DPP-4 inhibitors inoshanda nekudzivirira kuparara kwemaincretin mahomoni, akadai seglucagon-like peptide-1 (GLP-1), ayo ane basa rekukurudzira kuburitswa kwe insulin uye kudzvanyirira kugadzirwa kweglucagon.Nekudzivisa DPP-4, linagliptin inorebesa kuita kweiyi incretin hormones, zvichiita kuti pave nekuvandudzwa kwekutonga shuga muropa kune vanhu vane chirwere cheshuga 2. Linagliptin inowanzorongedzerwa sechikamu chekudya uye kurovedza muviri mukutarisira kwechirwere cheshuga 2.Iyo inozivikanwa kune yayo yakareba hafu yehupenyu, iyo inobvumira kamwe-zuva nezuva dosing nyore.Linagliptin yakaratidza kunyatsodzikisa hemoglobin A1c mazinga, chiratidzo chekugara kwenguva refu kweglucose, uye inowanzotenderwa nevarwere.Kushandiswa kweLinagliptin Yepakati F mukugadzirwa kwelinagliptin kunoratidza basa rayo rakakosha mukugadzirwa kwemushonga. izvo zvinogona kukanganisa zvakanyanya hupenyu hwevanhu vane Type 2 chirwere cheshuga.Nekubatsira pakusikwa kwemakemikari akasarudzika e linagliptin, iyi yepakati inoita kuti chigadzirwa chekupedzisira chikwanise kudzivirira DPP-4 uye kugadzirisa glycemic control.Pakupedzisira, Linagliptin Yepakati F ikemikari yakakosha mukuumbwa kwelinagliptin, DPP-4 inhibitor. rinoshandiswa kurapa Type 2 chirwere cheshuga.Basa rayo mukugadzira linagliptin's molecular structure inosimbisa kukosha kwayo mukugadzirwa kwemushonga unogona kuvandudza kudzora shuga yeropa uye kuwedzera hutungamiri hwechirwere cheshuga.Nekuvharira DPP-4, linagliptin inobatsira kudzora mazinga eglucose muropa uye inobatsira kuhutano hwese hwevanhu vane chirwere cheshuga chechipiri.