Metronidazole Cas: 443-48-1
| Catalog Number | XD91888 |
| Product Name | Metronidazole |
| CAS | 443-48-1 |
| Molecular Formula | C6H9N3O3 |
| Molecular Weight | 171.15 |
| Storage Details | 2-8°C |
| Harmonised Tariff Code | 29332990 |
Chigadzirwa Specification
| Chitarisiko | White crystalline powder |
| Assay | 99% min |
| Melting point | 159-161 °C (lit.) |
| Boiling point | 301.12°C (yakaomarara fungidziro) |
| density | 1.3994 (yakaomarara fungidziro) |
| refractive index | 1.5800 (kufungidzira) |
| Fp | 9℃ |
| solubility | acetic acid: 0.1 M, yakajeka, yakaderera yero |
| pka | pKa 2.62(H2O,t =25±0.2,Iundefined) (Hazvina chokwadi) |
| Mvura Solubility | <0.1 g/100 mL pa20 ºC |
Metronidazole mushonga wesarudzo weamebiases, vaginal trichomonasis uye trichomonadic urethritis muvarume, lambliosis, amebic dysentery, uye zvirwere zveanaerobic zvinokonzerwa nehutachiona husinganzwisisi mushonga.Mazwi akafanana emushonga uyu anoti flagyl, protostat, trichopol, uye vagimid.
Metronidazole inowanikwa mumuromo, intravaginal, topical, uye parenteral gadziriro.Inogadzirwa nemakambani akawanda, asi inongowanikwa chete nemishonga.Kusaziva kuratidzwa kwezvakatipoteredza hakugoneki, uye kana zvikaitika, hazvibviri kukonzera chepfu.
Inoshandiswa seantibacterial mukurapa rosacea.Antiprotozoal (trichomonas).Inogona kukonzera kenza yemunhu.
Metronidazole, inorwisa mabhakitiriya uye antiprotozoal agent.Inonyanya kushandiswa kurapa kana kudzivirira systemic kana yemunharaunda utachiona hunokonzerwa neanaerobic bacteria, senge anaerobic bacterial infections mudumbu remudumbu, digestive turakiti, yevakadzi reproductive system, rezasi rekufema turakiti, ganda uye zvinyoro zvinyoro, mapfupa nemajoini, etc. , zvirwere zvemeningeal, uye colitis inokonzerwa nekushandiswa kwemishonga inorwisa mabhakitiriya inoshandawo.Tetanus inowanzobatwa netetanus antitoxin (TAT).Inogona zvakare kushandiswa pamuromo anaerobic utachiona.Musi wa27 Gumiguru, 2017, rondedzero yecarcinogens yakaburitswa neWorld Health Organisation's International Agency for Research on Cancer yakatanga kurongerwa kuti itariswe, uye metronidazole yakaverengerwa mune rondedzero yekirasi 2B carcinogens.Muna Ndira 2020, metronidazole yakasarudzwa muchikamu chechipiri chenyika chepakati chekutenga zvinodhaka.
Metronidazole ndiyo inoshanda zvakanyanya inowanikwa pakurapa vanhu vane marudzi ese eamebiasis, pamwe kunze kwemunhu asina zviratidzo asi achiramba achiburitsa cysts.Mamiriro ezvinhu akadaro anoda intraluminal amebicide inoshanda, yakadai se diloxanide furoate, paromomycin sulfate, kana diiodohydroxyquin.Metronidazole inoshanda kurwisa intestinal uye extraintestinal cysts uye trophozoites.
Kunyange zvazvo quinacrine hydrochloride yakashandiswa pakurapa giardiasis, vanachiremba vakawanda vanoda metronidazole.Furazolidone imwe sarudzo.
Metronidazole mushonga wesarudzo muEurope kune anaerobic bacterial infection;kunetseka pamusoro pekubvira kwecarcinogenicity kwakatungamirira kune kumwe kuchenjerera mukushandiswa kwayo muUnited States.Nguva pfupi yapfuura yakaonekwa kuti inoshanda mukurapa D. medinensis (Guinea worm) zvirwere uye Helicobacter pylori.
Inoshandiswawo muacne rosacea, balantidiasis uye Guinea worm infection.T. vaginalis zvirwere zvinopesana nedosi yenguva dzose zvinoda kurapwa kwakakosha.
