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Carbonic anhydrase activators: yekutanga activation yekudzidza yemunhu secretory isoform VI ine amino acids uye amines.

Iyo secretory isozyme yemunhu carbonic anhydrase (hCA, EC 4.2.1.1), hCA VI, yakaumbwa, inoratidzwa, uye yakacheneswa muhurongwa hwekutaura kwebhakitiriya.Iyo kinetic parameters ye CO(2) hydration reaction yakaratidza hCA VI kuve ne ak(katsi) ye 3.4 x 10(5)s(-1) uye k(katsi)/K(M) ye 4.9 x 10(7)M (-1)s(-1) (pa pH 7.5 uye 20 madhigirii C).hCA VI ine basa rinokosha rinoita kuti pave nemaitiro emuviri, yehurongwa hwakafanana hwehukuru seubiquitous isoform CA I kana transmembrane, bundu-yakabatana isozyme CA IX.Nhevedzano yeamino acids uye amines yakaratidzwa kuita seCA VI activators, ine maitiro akasiyana.l-His, l-Trp, uye dopamine yakaratidza isina simba CA VI activating mhedzisiro (K (A) s muhuwandu hwe21-42 microM), nepo d-His, d-Phe, l-DOPA, l-Trp, serotonin. , uye mamwe pyridyl-alkylamines akanga ari nani activators, neK (A) s muhuwandu hwe13-19 microM.Iwo akanakisa CA VI activators aive l-Phe, d-DOPA, l-Tyr, 4-amino-l-Phe, uye histamine, ine K(A)s muhuwandu hwe1.23-9.31 microM.Ese aya ma activator anowedzera k(katsi), asina chekuita paK(M), achitora chikamu muyero yekutarisa nhanho mukutenderera kutenderera, maitiro ekutamisa proton pakati peiyo enzyme inoshanda saiti uye nharaunda.