N, N'-Methylenebisacrylamide Cas: 110-26-9 98% White powder
| Catalog Number | XD90231 |
| Product Name | N,N'-Methylenebisacrylamide |
| CAS | 110-26-9 |
| Molecular Formula | C7H10N2O2 |
| Molecular Weight | 154.1665 |
| Storage Details | 2 kusvika ku8 °C |
| Harmonised Tariff Code | 29241900 |
Chigadzirwa Specification
| Assay | >98% |
| Mvura isinganyunguriki | <0.5% |
| Chitarisiko | Upfu chena |
| Inorganic sulfates | <0.5% |
| Zvekutsvaga kushandiswa chete, kwete zvekushandisa kwevanhu | tsvakurudzo inoshandiswa chete, kwete yekushandiswa kwevanhu |
Basa rakakosha re tumor-yakabatana fibroblasts (TAF) mukufambira mberi kwegomarara rave pachena mune isiri-diki cell cancer yemapapu (NSCLC).Nekudaro, marapirwo anopesana neTAF ane mashoma nekuda kwekushaikwa kwekunzwisisa mune subtype-chaiyo nzira dziri pasi pekuunganidza kwavo.Pano, iyo mechanical (kureva, matrix rigidity) uye soluble mitogenic cues inofambisa kuunganidzwa kweTAFs kubva kune makuru NSCLC subtypes: adenocarcinoma (ADC) uye squamous cell carcinoma (SCC) yakaparadzaniswa.Mafibroblasts akagadzirwa pa substrata yakagadzirwa kuratidza zvakajairwa- kana bundu-sekuomarara kwakasiyana-siyana serum concentrations, uye dzakakosha kudzora maitiro akajekeswa.Mukudzora fibroblasts kubva munyama isina kusimba, matrix kuomarara kwega kwakawedzera fibroblast kuunganidzwa, uye iyi mechanical effect yaive yakakura kana kuenzaniswa neyezvinonyungudika kukura zvinhu zvinosvika 0.5% serum.Iyo inosimudzira cues ye matrix rigidity yaifambiswa ne β1 integrin mechano-sensing kuburikidza neFAK (pY397), uye yaibatanidzwa wit ha posttranscriptally inofambiswa ichikwira mu β1 integrin kutaura.Iyo yekupedzisira mechano-regulatory circuit yakaonekwawo muTAFs asi mune subtype-yakananga fashoni, nokuti SCC-TAFs yakaratidza yakakwirira FAK (pY397), β1 kutaura, uye ERK1/2 (pT202/Y204) kupfuura ADC-TAFs.Zvakare, kuomarara kwematrix kwakakonzera kuwanda kweTAF muSCC-TAFs (> 50%) zvichienzaniswa neADC-TAFs (10% -20%).Kusiyana neizvi, SCC-TAFs yaive yakanyanya serum deensitized, nepo ADC-TAFs yakapindura kune yakakwira serum concentration chete.Izvi zvakawanikwa zvinopa humbowo hwekutanga hwe subtype-yakananga mutemo weNSCLC-TAF kuunganidza.Uyezve, idzi data dzinotsigira kuti marapirwo ane chinangwa chekudzorera hutano hwemapapu uye / kana β1 integrin-dependent mechano regulation inogona kushanda paSCC-TAFs, asi inhibiting stromal growth factor signaling inogona kushanda kune ADC-TAFs. kuunganidzwa kusingaite kwebundu-inotsigira fibroblasts muzvikamu zviviri zvikuru zvegomarara remapapu, izvo zvichabatsira kuvandudzwa kwemishonga yemunhu kurwisa maseru aya.
