Products

Iyo inhibition ye β-carbonic anhydrases (CAs, EC 4.2.1.1) kubva kune pathogenic fungi Cryptococcus neoformans (Can2) uye Candida albicans (Nce103) ine mutsara we25 branched aliphatic uye inonhuwira carboxylates yakaongororwa.Isoforms dzevanhu hCA I uye II dzakabatanidzwawo muchidzidzo chekuenzanisa.Aliphatic carboxylates aiwanzo millimolar hCA I uye II inhibitors uye yakaderera micromolar/submicromolar β-CA inhibitors.Aromatic carboxylates aive micromolar inhibitors ema enzymes mana asi mamwe acho airatidza yakaderera nanomolar chiitiko kurwisa fungal pathogenic enzymes.4-Hydroxy- uye 4-methoxy-benzoate yakavharirwa Can2 ine K(I)s ye9.5-9.9 nM.Iyo methyl esters, hydroxamates, hydrazides uye carboxamides yemamwe ezvinobvamo aya aivewo anoshanda inhibitors eiyo α- uye β-CAs akaongororwa pano.

Maparabens ari pakati peanonyanya kushandiswa kuchengetedza kuvharidzira kukura kwehutachiona uye kuwedzera hupenyu hwesherufu yemhando dzakasiyana dzezvigadzirwa zvevatengi.Chinangwa chechidzidzo chiripo ndechekuwana ruzivo rwemetabolism yeparabens mumasero ekenza yemazamu (MCF7) sezvo vakaratidza basa reestrogenic kune aya maseru uye vakaonekwa mumatumbu ekenza yemazamu.Kutyisa kweparabens kune MCF7 masero kwakatemwa uchishandisa MTT assays.Hydrolysis yemethyl-, butyl uye benzyl-paraben kune p-hydroxybenzoic acid yakaongororwa mumaseru akagadzirwa MCF7 uye mumaserura homogenates.Glucuronidation uye sulfoconjugation zvakadzidzwa muMCF7 homogenates, uye parabens yakaongororwa neHPLC.Methyl-paraben yakaratidzwa kuva yakanyanya kuchetura kupfuura butyl uye benzyl-paraben.Maparabens aive akanyatsogadzikana muMCF7 homogenates nepo p-nitrophenyl acetate, substrate type, yakaitwa hydrolysis.MCF7 cell homogenates haina kuratidza glucuronidation uye sulfoconjugation zviitiko kune parabens.Kugadzikana kwepamusoro kweparabens kunogona kutsanangura kuunganidza kwavo mukenza yemazamu.