Phosphatase, alkaline CAS:9001-78-9 chena, grey chena kana peach monoclinic crystal kana upfu
| Catalog Number | XD90379 |
| Product Name | Phosphatase, alkaline |
| CAS | 9001-78-9 |
| Molecular Formula | C21H36N8O6 |
| Molecular Weight | 496.57 |
| Storage Details | 2 kusvika ku8 °C |
| Harmonised Tariff Code | 35079090 |
Chigadzirwa Specification
| Assay | 99% |
| Chitarisiko | chena, grey chena kana peach monoclinic crystal kana upfu |
Kunyange zvazvo fluoride ichizivikanwa kuti inokurudzira kuumbwa kwemapfupa, maitiro epasi haanzwisisiki zvakakwana.Zvidzidzo zvenguva pfupi yapfuura zvakabatanidza nzira yeWnt/β-catenin senzira huru yekusaina mubhaibheri remapfupa.Zvidzidzo zvedu zvepakutanga zvakaratidza basa rinogoneka reCanonical Wnt nzira mukuumbwa kwepfupa remakonzo asingaperi fluoride-akafumurwa, asi nzira yacho inoramba isina kujeka.Chidzidzo chezvino chakagadzirisa kubatanidzwa kweWnt / β-catenin kuisa chiratidzo mu fluoride-induced osteoblastic differentiation.Tichishandisa maprimary rat osteoblasts, takaratidza kuti fluoride yakasimudzira zvakanyanya osteoblasts kuwanda uye alkaline phosphate (ALP) kutaura pamwe nemRNA matauriro emazinga ekusiyanisa mapfupa, kusanganisira mhando I collagen (COL1A1), ALP uye osteonectin.Takazowana zvakare fluoride induced phosphorylations pa serine 473 yeAkt uye serine 9 ye glycogen synthase kinase-3β (GSK3β), iyo yakaguma neGSK-3β inhibition uye pakupedzisira kuunganidza nyukireya ye β-catenin, sezvakaratidzwa neWestern blot uye immunofluoresce. .Uyezve, fluoride yakakonzerawo kutaura kweWnt-targeted gene run-related transcription factor 2 (Runx2).Zvinonyanya kukosha, mhedzisiro yakanaka yefluoride pane ALP chiitiko uye mRNA kutaura kweCOL1A1, ALP, osteonection uye Runx2 yakabviswa neDKK-1, blocker yeWnt/β-catenin receptor.Kutorwa pamwe chete, izvi zvakawanikwa zvinoratidza kuti fluoride inokurudzira osteoblastic kusiyanisa kuburikidza neAkt- uye GSK-3β-inotsamira activation yeWnt / β-catenin inoratidzira nzira muprimary rat osteoblasts.Zvatinowana zvinopa ruzivo rutsva mumaitiro ekuita kwefluoride mu osteoblastogenesis.
