Poly-L-lysine mhinduro ( 0.1%) Cas: 25988-63-0
| Catalog Number | XD90306 |
| Product Name | Poly-L-lysine mhinduro (0.1%) |
| CAS | 25988-63-0 |
| Molecular Formula | C18H38N6O4 |
| Molecular Weight | 402.532124042511 |
| Storage Details | 2-8°C |
Chigadzirwa Specification
| Assay | 0.1% |
| Chitarisiko | Mvura isina ruvara |
eucine-rich repeat kinase 2 (LRRK2) mutations ndiyo inonyanya kuzivikanwa chikonzero cheParkinson's disease (PD).Zvimiro zvekiriniki zveLRRK2 PD hazvizivikanwe kubva kune idiopathic PD, nekuunganidzwa kwe-α-synuclein uye/kana tau uye/kana ubiquitin mune intraneuronal aggregates.Izvi zvinoratidza kuti LRRK2 ndiyo kiyi yekunzwisisa aetiology yechirwere.Kunyange zvazvo kurasikirwa-kwe-basa kusingaoneki ndiyo nzira inokonzera PD muvarwere veLRRK2, hazvisi pachena kuti puroteni iyi inopindirana sei nehupfu.Muchidzidzo ichi, tinoshuma kuti LRRK2 overexpression mumasero uye muvivo inokanganisa basa reubiquitin-proteasome nzira, uye kuti izvi zvinokonzera kuunganidzwa kwezvikamu zvakasiyana-siyana neLRRK2 overexpression.Isu tinoratidza kuti izvi hazvina kupindirana nehukuru LRRK2 aggregates kana sequestration ye ubiquitin kune akaunganidzwa.Zvakakosha, izvo zvisiri izvo hazvionekwe nekuwedzeredza kweprotein yakabatana LRRK1.Yedu data inoratidza kuti LRRK2 inhibisa kubvumidzwa kweproteasome substrate s kumusoro kweproteasome catalytic chiitiko, ichifarira kuunganidzwa kweprotein uye kuumbwa kwakaunganidzwa.Nokudaro, tinopa ma molecular link pakati peLRRK2, iyo inonyanya kuzivikanwa chikonzero chePD, uye yakambotsanangurwa phenotype yeprotein accumulation.
